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Novel Selective Estrogen Receptor Modulators SERMs

Annual Reports in Medicinal Chemistry, Volume 42 ISSN 0065-7743, DOI 10.1016/S0065-7743(07)42010-3 [Pg.147]

Novel Selective Estrogen Receptor Modulators (SERMs)... [Pg.147]

A Bischler-Mohlau indole synthesis was also pivotal in constructing the indole ring of bazedoxifene acetate (Viviant), Wyeth s novel and highly selective indole estrogen. It is a selective estrogen receptor modulator (SERM) for the treatment of and prevention of osteoporosis. It was found... [Pg.73]

The clinical significance of the selective estrogen receptor modulators (SERMs) is well documented. The intensive research is currently directed at discovery of the ideal SERM , an agent that is antiestrogenic in breast and endometrial tissue, but pro-estrogenic in the vasculature and brain, which would be of use as a preventative in breast and uterine cancer and an alternate attractive HRT. Compound 1-(R) is a backup development candidate of the bisbenzopyran lead compound in our SERM program. This compound has shown promising preclinical profile with excellent pharmacokinetic properties. The identification and profiles of this novel SERM will be discussed. [Pg.164]

See other pages where Novel Selective Estrogen Receptor Modulators SERMs is mentioned: [Pg.1113]    [Pg.147]    [Pg.1113]    [Pg.916]    [Pg.210]    [Pg.1667]    [Pg.163]    [Pg.163]    [Pg.1324]   


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Estrogen SERMs

Estrogen receptor

Estrogen receptor (3-modulator

Estrogen receptor modulation

Estrogen receptor modulators

Estrogen receptor modulators, SERMS

Selective estrogen receptor

Selective estrogen receptor modulator

Selective estrogen receptor modulator SERM)

Selective estrogen receptor modulators

Selective estrogen receptor modulators SERM)

Selective estrogen receptor modulators SERMs)

Selective receptors

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