Selective estrogen-receptor chemistry

Musa, M. A., Khan, M. O., Cooperwood, J. S. Medicinal chemistry and emerging strategies applied to the development of selective estrogen receptor modulators (SERMs). Curr. Med. Chem. 2007, 14, 1249-1261. 

Jordan, V.C. (2003) Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 2. Clinical considerations and new agents. Journal of Medicinal Chemistry, 46, 1081-1111. 

Malamas, M., Manas, E., McDevitt, R., Gunawan, I., Xu, Z., Collini, M., Miller, C., Dinh, T. et al. (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-p ligands. Journal of Medicinal Chemistry, 47, 5021-5040. 

Wijayaratne, A.L. and McDonnell, D.P. (2001) The human estrogen receptor-a is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. The Journal of Biological Chemistry, 276, 35684—35692. 

Jordan VC. Selective estrogen receptor modulators. In Williams DA, Lemke T, eds. Foye s Principles of Medicinal Chemistry. Baltimore Lippincott Williams Wilkins, 2002 1059-1069. 

Williams, S.P., Wisely, G.B. and Lambert, M.H. (2002) A new series of estrogen receptor modulators that display selectivity for estrogen receptor p. Journal of Medicinal Chemistry, 45, 5492-5505. 

Geistlinger, T.R., McReynolds, A.C. and Guy, R.K. (2004) Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms. Chemistry et Biology, 11,273-281. 

Stauffer, S.R., Coletta, C.J., Tedesco, R., Nishiguchi, G., Carlson, K Sun, J Katzenellenbogen, B.S. and Katzenellenbogen, J.A. (2000) Pyrazole ligands structure-affinity/activity relationships and estrogen receptor-a-selective agonists. Journal of Medicinal Chemistry, 43, 4934-4947. 

DaSilva, C.A., Pai, L.Y. et al. (2007) Estrogen receptor ligands. Part 16 2-aryl indoles as highly subtype selective ligands for ERa. Bioorganic el Medicinal Chemistry Letters, 17, 2322-2328. 

Renaud, J., Bischoff S.F., Buhl, T., Floersheim, P., Fournier, B., Halleux, C., Kallen, J., Keller, H. et al. (2003) Estrogen receptor modulators identification and structure-activity relationships of potent ERa-selective tetrahydroisoquinoline ligands. Journal of Medicinal Chemistry, 46, 2945-2957. 

Zuercher, W.J., Gaillard, S., Orband-Miller, L.A., Chao, E.Y., Shearer, B.G., Jones, D.G., Miller, A.B., Collins, J.L. et al. (2005) Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRfJ and ERRy. Journal of Medicinal Chemistry, 48, 3107-3109. 

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