Selection biotechnology

Dimensional analysis is a useful tool for examining complex engineering problems by grouping process variables into sets that can be analyzed separately. If appropriate parameters are identified, the number of experiments needed for process design can be reduced, and the results can be described in simple mathematical expressions. In addition, the application of dimensional analysis may facilitate the scale-up for selected biotechnology unit operations. A detailed description of dimensional analysis is reviewed by Zlokarnik [18]. 

Lipinski, C.A. 2004. Solubility in water and DMSO issues and potential solutions. In Borchardt, RT. et al., Eds. Pharmaceutical Profiling in Drug Discovery for Lead Selection Biotechnology. Arlington AAPS Press, pp. 93-125. 

The returns of the publicly-traded biotech venture capital funds - of which we found approximately ten - are comparable to the returns on an average venture capital fund. Fidelity Select Biotechnology, for example, recorded a 26.3 percent average annual return over a five-year period (Fig. 6.1). 

Other selected biotechnological companies are listed below in chronological order. 

On the basis of experimental data, using the calculation method of chemical reaction kinetics, the kinetic parameters of thermal inactivation of many substances were established (Table 45.3) [20]. However, the authors make reference to a high discrepancy of experimental and calculated data, reaching 20%-30%. Similar kinetic parameters were determined as a result of investigations of selected biotechnological products [43 6]. 

Manufacturing approaches for selected bioproducts of the new biotechnology impact product recovery and purification. The most prevalent bioseparations method is chromatography (qv). Thus the practical tools used to initiate scaleup of process Hquid chromatographic separations starting from a minimum amount of laboratory data are given. 

Table 9.1 The use of modified sterols to allow selective cleavage of the side chain (based on Martin, CKA Sterols in Biotechnology Volume 6a Edited by Kieslich K1984 Verlag Chemie, Weinheim).

Airlift loop reactor (ALR), basically a specially structured bubble column, has been widely used in chemical industry, biotechnology and environmental protection, due to its high efficiency in mixing, mass transfer, heat transfer etc [1]. In these processes, multiple reactions are commonly involved, in addition to their complicated aspects of mixing, mass transfer, and heat transfer. The interaction of all these obviously affects selectivity of the desired products [2]. It is, therefore, essential to develop efficient computational flow models to reveal more about such a complicated process and to facilitate design and scale up tasks of the reactor. However, in the past decades, most involved studies were usually carried out in air-water system and the assumed reactor constructions were oversimplified which kept itself far away from the real industrial conditions [3] [4]. 

From this one ancestral fungus each penicillin manufacturer has evolved a particular production strain by a series of mutagenic treatments, each followed by the selection of improved variants. These selected variants have proved capable of producing amounts of penicillin far greater than those produced by the wild strain, especially when fermented on media under particular control conditions developed in parallel with the strains. These strain selection procedures have become a fundamental feature of industrial biotechnology. 

---