Segregation avoidance

Ingredient Segregation Avoided Powders such as hypromellose and titanium dioxide exhibit dramatically different particle size distribution and density. Such particle heterogeneity may result in constituent segregation inducing film imperfections or color deviations on tablets. 

Generally, it is more economical to prevent explosive atmospheres ia rooms than to try to provide explosion-proof electrical equipment. Personnel should never be allowed to work ia a ha2ardous atmosphere. Where such an atmosphere cannot be avoided through control of flammable Hquids, gases, and dusts, access to the area iavolved should be limited and the area segregated by hoods or special ventilation. Electrical equipment on open, outdoor stmctures more than 8 m above-ground usually is considered free from exposure to more than temporary, local explosive mixtures near leaks (86). 

An ingenious method to avoid or reduce segregation of alloying elements involves preparing small spheres of material by the atomization of a Hquid stream through a nozzle to produce a powder. This powder can be compacted, often hot and triaxially by gas pressure, to form a material where, on further heating, the residual pores close by diffusion to approach 100% density. 

The oxychlorination reaction is very exothermic and the catalyst is very active, which makes it necessary to mix the catalyst with an inert diluent to avoid overheating in a fixed-bed reactor. A low surface area, spherically- or ring-shaped alumina or chemical porcelain body can be used as a diluent with the ring-shaped catalyst. The density of the inert material should be similar to the catalyst to avoid segregation during loading, and the size should be slightly different to allow separation of the inert material from the spent catalyst. 

Keep flammable chemicals apart from oxidizing agents Design layout to avoid domino effects/fire spread Segregate empty and full containers... 

Minimize stocks and segregate from other chemicals and work areas. Where appropriate, keep samples dilute or damp and avoid formation of large crystals when practicable. Add stabilizers if possible, e.g. to vinyl monomers. Store in specially-designed, well-labelled containers in No Smoking areas, preferably in several small containers rather than one large container. Where relevant, store in dark and under chilled conditions, except where this causes pure material to separate from stabilizer (e.g. acrylic acid). 

Segregation simply refers to avoiding the mixing of streams. In many cases, segregating waste streams at the source renders several streams environmentally acceptable and hence reduces the pollution-prevention cost. Furthermore, segregating streams with different compositions avoids unnecessary dilution of streams. This reduces the cost of removing the pollutant from the more concentrated streams. It may also provide composition levels that allow the streams to be recycled directly to process units. 

Set up procedures to prevent inadvertent introduction of other ignition sources and to avoid oxygen enrichment Physical segregation, e.g. fences... 

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