Sedation excessive daytime

Patients should be advised to administer interferon in the evening to reduce excessive daytime sedation premedication and scheduled dosing with acetaminophen or an NSAID may alleviate flu-like symptoms... 

Pharmacodynamic interactions. Many TCAs cause sedation and therefore co-prescription with other sedative agents such as opioid analgesics, antihistamines, anxiolytics, hypnotics and alcohol may lead to excessive drowsiness and daytime somnolence. The majority of TCAs can have undesirable cardiovascular effects, in particular prolongation of the QT interval. A similar risk of QT prolongation arises with many other cardiovascular drugs including amiodarone, disopyramide, procainamide, propa-... 

Side effects are dose dependent and vary according to the pharmacokinetics of the individual benzodiazepine. High doses with long or intermediate elimination half-lives have a greater potential for producing daytime sedation and performance impairment. These effects include excessive drowsiness, psychomotor incoordination, decreased concentration, and cognitive deficits. Tolerance may develop with time. Rapidly eliminated benzodiazepines have less potential for daytime sedation."... 

Psychomotor dysfunction This includes cognitive impairment, decreased psychomotor skills, and unwanted daytime sedation. These adverse effects are more common with benzodiazepines that have active metabolites with long half-lives (eg, diazepam, flurazepam). The dosage of a sedative-hypnotic should be reduced in elderly patients to avoid excessive... 

Five out of 16 patients receiving fluoxetine stopped taking trazodone 25 to 75 mg, which was given for insomnia, because of excessive sedation the next day. Three out of 8 patients had improvement in sleep and depression when given both drugs but the other 5 were either unaffected or had intolerable adverse effects (headaches, dizziness, daytime sedation, fatigue). However, another report described advantageous concurrent use in 6 patients without an increase in adverse effects. ... 

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