Second primary malignancies

Guinan P, Brosman S, DeKernion J, Lamm D, Williams R, Richardson C, Reitsma D, Hanna M. Intravesical Bacillus Calmette-Guerin and second primary malignancies. Urology 1989 33(5) 380-1. 

Khanna OP. Intravesical BCG and second primary malignancies. Urology 1989 34(2) 113. 

Rutqvist, L.E., Johansson, H., Signomklao, T., Johansson, U., Fornander, T. and Wilking, N. (1995) Adjuvant tamoxifen therapy for early stage breast cancer and second primary malignancies. Stockholm Breast Cancer Study Group. Journal of the National Cancer Institute, 87, 645-651. 

Second primary malignancies A radioactive isotope of technesium... 

Rubino et al. (2003) evaluated the risk of second primary malignancies (SPM) in 6841 thyroid cancer patients... 

Hartman DS, Davis CJ Jr, Madewell JE et al (1982) Primary malignant renal tumors in the second decade of life Wilms tumor versus renal cell carcinoma. J Urol 127(5) 888-891... 

The liver is host to a wide variety of both benign and malignant primary tumors. It is also the second most common site of metastases metastatic tumors account for 90% to 95% of all hepatic malignancies. The primary tumors may arise from many cell lines in the liver but most commonly from parenchymal and biliary epithelial cells and mesenchymal cells (Table 47-10). The two most important primary liver tumors are HCC and cholangiocarcinoma. 

The second main aspect of adhesion in medicine corresponds to the cellular level. A few examples will be given. In the development of a cancer, one major problem is that the patient is often only aware of the primary tumour when it has evolved sufficiently for metastases to have been released. These malignant cells are free to migrate within the body, often in the blood circulation, and create secondary tumours elsewhere in the body leading to a generalized iUness. Were we able to increase the adhesion of metastases to their source, many treatments of cancer could be limited to a specific area of the body. By contrast, consider a case where adhesion is undesirable. Heart disease is often related to the blocking of arteries by matter, in particular thrombi, or locally produced blood clots. 

Trojaborg, the main difference between the two types is the rate of firing. The benign ones fire approximately every second, while the malignant ones occur approximately every 3 to 5 seconds. They are not seen in primary muscle disease (Preston Shapiro, 2005). 

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