Secoisolariciresinol diglycoside

Tou, J.C., Chen, J., and Thompson, L.U., Flaxseed and its lignan precursor, secoisolariciresinol diglycoside, affect pregnancy outcome and reproductive development in rats, J. Nutr., 128, 1861, 1998. 

Kitts, D.D., Yuan, Y.V., Wijewickreme, A.N., and Thompson, L.U. 1999. Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol... 

Rickard, S. and Thompson, L. 2000. Urinary composition and postprandial blood changes in 3H-secoisolariciresinol diglycoside (SDG) metabolites in rats do not differ between acute and chronic SDG treatments. J. Nutr. 130, 2299-2305. 

Rickard, S.E., Orcheson, L.J., and Seidl, M.M. 1996. Dose-dependent production of mammalian lignans in rats and in vitro from the purified precursor secoisolariciresinol diglycoside in flaxseed. 

HPLC coupled with either ionspray or continuous-flow FAB-MS or gas chromatography (GC)-MS using single ion monitoring allowed rapid detection and identification of secoisolariciresinol diglycoside in flaxseed. Two diastereoisomers of secoisolariciresinol diglycoside were detected by this method [47,48],... 

In an in vivo study, Jenab et al. [150] demonstrated the protective effects of flaxseed lignans against colon cancer. This was associated with an increase in P-glucuronidase activity. The total activity of this enzyme correlated positively with total urinary lignan excretion, especially secoisolariciresinol diglycoside, and negatively with the total number of aberrant crypts and the total number of aberrant crypt foci in the distal colon. 

Flaxseed contains the compound secoisolariciresinol diglycoside (SDG), which is converted by bacteria in the colon to the mammalian lignans enterodiol and enterolactone, compounds that have phytoestrogenic activity (Power and Thompson 2007). 

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