78-92-2 sec-Butyl alcohol

Reflux a mixture of 68 g. of anhydrous zinc chloride (e.g., sticks), 40 ml. (47 -5 g.) of concentrated hydrochloric acid and 18-5 g. (23 ml.) of sec.-butyl alcohol (b.p. 99-100°) in the apparatus of Fig. 777, 25, 1 for 2 hours. Distil oflF the crude chloride untU the temperature rises to 100°. Separate the upper layer of the distillate, wash it successively with water, 5 per cent, sodium hydroxide solution and water dry with anhydrous calcium chloride. Distil through a short column or from a Claisen flask with fractionating side arm, and collect the fraction of b.p. 67-70° some high boiling point material remains in the flask. Redistil and collect the pure cc. butyl chloride at 67-69°. The yield is 15 g. 

You see that substrate they were using sec-butyl alcohol" Well to Strike that looks just like MD-P2Pol ... 

So if one were to replace sec-butyl alcohol in the recipe above with an equimolar amount of safrole in the above reaction, Strike will wager that a positive bromination experience will occur. And all this using the very common 48% aq. HBr The oniy difference being that once the reaction mix had cooled, one should do either of two things (1) distill as described except the bromosafrole will be the last thing to come over (not the first), or (2) flood the reaction mix with water to bring the product out of solution after which it can be physically separated by decanting or sep funnel or some such shit. 

Substitutive name Functional class names 1 Butanol n Butyl alcohol or butyl alcohol 2 Butanol sec Butyl alcohol or 1 methylpropyl alcohol... 

One 1-ml aliquot is added to 1.0 ml of freshly-distilled 1,2-dibromo-ethane (bp 132°C) in an oven-dried flask which contains a static atmosphere of nitrogen or argon. After the resulting solution has been allowed to stand at 25°C for 5 min, it Is diluted with 10 rat of water and titrated for base content (residual base) to a phenolphthalein endpoint with standard 0.100 M hydrochloric acid. The second 1-mL aliquot is added cautiously to 10 ml of water and then titrated for base content (total base) to a phenol phthalein endpoint with standard aqueous 0.100 M hydrochloric acid. The methyllithium concentration is the difference between the total base and residual base concentrations.2 Alternatively, the methynithiura concentration may be determined by titration with a standard solution of sec-butyl alcohol employing 2,2 -bipyridyl as an indicator. 

Methanol, ethanol, isopropyl alcohol, n-propyl alcohol, sec-butyl alcohol, n-butyl alcohol... 

Crotonic acid, esterification with sec-butyl alcohol, 41, 60 Crystal Violet, from condensation of oxalyl chloride with dimethyl-aniline, 41, 2-4... 

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