SEB toxin

Medical Management Victims may have a feverish respiratory syndrome without chest x-ray abnormalities, and diagnosis is usually clinical. Medical and emergency medical services personnel should be aware of and should report any number of victims showing up within a limited amount of time presenting typical symptoms and instances of SEB pulmonary exposure as being indicative of being an intentional attack with SEB toxin. 

Purified SEB toxin is a white, fluffy material that is water soluble. It is stable to heat and cold as well as in both high and low pH. 

SEB infection has a tendency to develop quickly due to a somewhat unchanging clinical condition. Respiratory difficulties occur much later with SEB inhalation. Laboratory testing will provide limited data for diagnosing the disease. SEB toxin is difficult to detect in serum when symptoms develop however, a baseline specimen for antibody detection should be drawn anyway as early as possible after exposure. Additional specimens should be drawn during recovery. SEB can be detected in the urine, and a sample should be taken and tested. Test results may be helpful retrospectively in developing a diagnosis. High concentrations inhibit kidney function. Disinfectant solutions include 0.5% sodium hypochlorite for 10 to 15 minutes or soap and water. 

As a potential biological weapon, aerosolized SEB toxin would present a significant hazard. Inhaling SEB could cause 80 percent or more of targeted personnel to become extremely ill within 3 to 12 hours, with possibly even more dire consequences than other routes of intoxication. The toxin is relatively heat-resistant, and very small quantities can produce severe illness.These... 

Toxins (typically high molecular weight proteins), such as botulinum toxin, ricin, or Staphyloccocal enterotoxin (SEB) or T-2 toxin (which actually is a small molecule). 

Biological Agents BACTERIA (Anthrax, Brucellosis, Cholera, Plague, Tularemia). VIRUSES (Crimean-Congo Hemorrhagic Fever, Rift Valley Fever, Smallpox, Venezuelan Equine Encephalitis (VEE), Viral Hemorrhagic Fever (Ebola)). TOXINS (Botulinum, Ricin, Staphylococcal Enterotoxin B (SEB), Trichothecene Mycotoxins/T-2). 

SEs are produced during the late log or stationary phase, and SE production is strain-dependent. SEB and SEC are produced in great quantities. Toxins such as SED occur in small amounts (Su and Wong, 1993), and so cases of poisoning are underreported due to the mild symptoms of intoxication they produce. 

Detection of staphylococcal enterotoxin B (SEB), a causative agent of food poisoning, was achieved by QDs conjugated with polyclonal sheep anti-SEB antibody.57 Moreover, this approach also harbors the possibility of a multiplexed immunoassay (see Fig. 12.3), which was first reported by Goldman et al.58 in 2004 four toxins of interest in food- or water-borne illnesses (cholera toxin, ricin,... 

Epsilon toxin from Clostridium perfringens (CDC Category B) Staphylococcal enterotoxin B (SEB) (CDC Category B) Diphtheria toxin Tetanus toxin Shigatoxin (veratoxin)... 

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