Screening Sigmoidoscopy

Selby JV, Friedman GD, Quesenberry CP, Weiss NS. A case-control study of screening sigmoidoscopy and mortality from colorectal cancer. N Engl J Med 1992 326 653-657. 

Doria-Rose, V. R, Levin, T. R., Selby, J. V., Newcomb, P. A., Richert-Boe, K. E., and Weiss, N. S. (2004). The incidence of colorectal cancer following a negative screening sigmoidoscopy Implications for screening interval. Gastroenterology 127, 714-722. 

Newcomb PA, Norfleet RG, Storer BE, Surawicz T, Marcus PM (1992) Screening sigmoidoscopy and colorectal cancer mortality. J Natl Cancer Inst 84 1572 1575... 

Atkin WS, Hart A, Edwards R, Cook CF, Wardle J, McIntyre P, Anbrey R, Baron C, Sutton S, Cuzick J, Senapati A, Northover JM. Single blind, randomised trial of efficacy and acceptabihty of oral picolax versus self administered phosphate enema in bowel preparation for flexible sigmoidoscopy screening. BMJ 2000 320(7248) 1504-9. 

If the mutation in the family cannot be identified, DNA linkage studies may be useful for presymptomatic identification of at-risk faintly members. If the mutation in the family cannot be identified and if DNA linkage studies are not informative or available, screening is recommended with yearly sigmoidoscopy as early as age 12. Further, when repeatedly negative sigmoidoscopy results are found, the frequency of such exams can be reduced in each subsequent decade of life. 

Elwood Ml, Ali G, Schlup MT et al (1995) Flexible sigmoidoscopy or colonoscopy for colorectal screening a randomized trial of performance and acceptability. Cancer Detec... 

Evidence-based comparisons with existing approved screening tests (FOBT, flexible sigmoidoscopy, double contrast barium enema, colonoscopy) will show that none is perfect and that CTC has a sufficient number of benefits and unique attractions to make it a legitimate addition. 

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