Screening coupling

Tsao DH et al (2006) Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design. Bioorg Med Chem 14(23) 7953-7961... 

This complex method originally used a particularly unpleasant-smelling thiol, now replaced with phloroglucinol, which is easier to use. The results obtained are identical, as the limiting factor is the acid lysis of the polymers. Molecular screening coupled with phloroglucinolysis provides data on polymer composition. The MDP of 80 for skin tannins was not confirmed by molecular screening. 

The static polarizabiliy of icosahedral fullerenes from Cgo to C2160 has been characterized using density functional theory in combination with both unscreened (uncoupled) and screened (coupled) approaches. In particular, a simple expression has been employed to estimate screened RPA values from the unscreened quantities. This expression uses an effective radius, which is determined from comparing the polarizability... 

Here A is a polarization index and g is the screened coupling constant gppi /V (q). In the following, the polarization index will be dropped and -Q.q . will be approximated by a single dispersionless exciton frequency ex ... 

Simulations of that kind result in a wide variety of A-scans and wavefront snapshots. The first screening of this material reveals, that the simulations in which the transducer is coupling partly to the V-butt weld and partly to the steel exhibit quite a number of pulses in the A-scans because the coupling at the interface of the weld results — due to the anisotropic behavior of the weld — in a complicated splitting of the transmitted wavefront. The different parts of the splitted wavefront are reflected and diffracted by the backwall, the interface, and — if present — by the notch and, therefore, many small signals are received by the transducer, which can only be separated and interpreted with great difficultie.s. 

Screen drive motor Variable speed coupling... 

An x-ray area detector can be used to collect the intensities of many reflections at a time. The crystal must be oriented in many different settings with respect to the incident beam but the detector needs to be positioned at only a few positions to collect all of the data. A charge coupled device (CCD) is used as the area detector on the Siemens SMART single crystal diffractometer system. The SMART detector consists of a flat 6-cm circular phosphorescent screen that converts x-ray photons to visible light photons. The screen is coupled to a tapered fiber optics bundle which is then coupled to a one inch by one inch square CCD chip. The CCD chip has 1024 x 1024 pixels each of which stores an electrical charge proportional to the number of... 

O. R. Queckenberg and A. W. Eraham, Cliromatographic and specti oscopic coupling a powerful tool for the screening of wild amaryllidaceae, J. Planar Chromatogr. 6 55-61 (1993). 

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