Screen to lead

A Real Time X-Ray Inspection System is introduced to replace Film X-Ray. The main objective is to reduce the consumption of film and to reduce the environmental pollution due to lead intensifying screens and chemicals. Other benefits are the reduction of space to storage X-ray data and the shorter inspection time, which gives a faster feed back to production. 

The sensitivity of the luminescence IP s in the systems employed here decreases with increasing x-ray energy more strongly than in the case of x-ray film. Therefore, this phenomenon must be compensated by using thicker lead front and back screens. The specific contrast c,p [1,3] is an appropriate parameter for a comparison between IP s and film, since it may be measured independently of the spatial resolution. Since the absorption coefficient p remains roughly constant for constant tube voltage and the same material, it suffices to measure and compare the scatter ratio k. Fig. 2 shows k as a function of the front and back screen thickness for the IP s for 400 keV and different wall thicknesses. The corresponding measured scatter ratios for x-ray films with 0,1 mm front and back screens of lead are likewise shown. The equivalent value for the front and back screen thicknesses is found from the intersection of the curves for the IP s and the film value. 

The antineoplastic agent mitindomide (160) in fact represents the well-known product from irradiation of maleimide in benzene [30]. The activity of this old compound was uncovered by one of the large antitumor screens maintained by the National Cancer Institute, The structure is sufficiently complex and the starting materials sufficiently available to lead one to suspect that the product is still produced photochemically. The product can be rationalized by assuming successive 1,4 and 1,2 additions to benzene. Intermediate 159a involves the 1,4 followed by 1,2 addition intermediate 159b presupposes the steps occur in the reverse order. 

Some types of screens used in hit to lead are controversial and are used in some organizations but not in others. Examples of these are ... 

A detailed screening pathway starting with a screen to generate hits and culminating in leads is also important for guiding lead generation efforts. An example is illustrated in Fig. 1. 

Starting with the crystal structure of the target, it is possible to screen for leads in three-dimensional compound databases such as the Cambridge... 

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