Schizophrenia serotonin receptors

Mecfianism of Action A piperazine derivative that antagonizes alpha-adrenergic, dopamine, histamine, and serotonin receptors also inhibits reuptake of serotonin and norepinephrine. Therapeutic Effect Diminishes symptoms of schizophrenia and depression. 

Atypical neuroleptics. Because of the limited effectiveness and safety of conventional neuroleptics in TS, clinicians have turned to a new generation of neuroleptics that have been introduced for the treatment of schizophrenia. Risperidone, a member of a class of antipsychotics that blocks both DA and serotonin receptors, has been established as superior to placebo and equal, or superior, to haloperidol in the treatment of schizophrenia (Chouinard et al. 1993 Marder and Meibach 1994]. Risperidone has a more favorable side-effect profile than that of conventional neuroleptics and may have less potential for producing tardive dyskinesia. Compared with haloperidol, fewer extrapyramidal side effects are observed with risperidone in doses of 6 mg/ day or less. As encouraging reports appear in the literature (Lombroso et al. 1995 Stamenkovic et al. 1994 van der Linden et al. 1994], risperidone is currently being widely used by clinicians to treat tic disorders. 

Ohouha DC, Hyde TM, Kleinman JE The role of serotonin in schizophrenia an overview of the nomenclature, distribution and alterations of serotonin receptors in the central nervous system. Psychopharmacology 112 S5-S15, 1993... 

Meltzer HY et al Serotonin receptors Their key role in drugs to treat schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2003 27 1159. [PMID 14642974]... 

Extension of this specificity principle to the clinical domain has resulted in the availability of increasingly well-aimed chemical bullets. If we wanted to block just one of the many serotonin receptors to see what would happen, we could probably do it But if we wanted to elevate mood in depression—or obsessive-compulsive disorder—would we expect the best result if we blocked just that one receptor And if we wanted to discourage auditory hallucinations in schizophrenia, would we want our drug to target only D2 dopamine receptors, even if we knew that the antipsychotic action of drugs correlated well with a drug s affinity for those receptors ... 

Few strong biological findings demonstrating lesions in specific psychiatric disorders Example discovery of changes in serotonin receptors and metabolites in depression, schizophrenia, and suicidal behavior... 

It may be concluded that despite the importance of the dopamine hypothesis of schizophrenia in serving to unify the mechanism of action of both typical and atypical neuroleptics, it is apparent that some serotonin receptor subtypes, and glutamate receptors of the NMDA subtype, may also play a crucial role. 

Verga M, et al. No association between schizophrenia and the serotonin receptor 5HTR2a in an Italian population. Am J Med Genet 1997 74(l) 21-25. 

Murad I, et al. A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia. Am J Med Genet 2001 105(3) 236—238. 

The 5-HT1A receptor is a member of the 5-HT] family of serotonin receptors best known for their capacity to inhibit adenylyl cyclase activity via pertussis toxin-sensitive G proteins. These receptors also couple to K+ channels, Ca2+ channels, PLC, intracellular calcium, mitogen-activated protein kinase cascade, and Na+/K+-ATPase (73,74). This receptor is an important target for the management of anxiety, depression, and schizophrenia (75-78). 

Roth BL, Hanizavareh SM, Blum AE. Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders. Psychopharmacology (Berl) 2004 174 17-24. 

Kasper S, Tauscher J, Kufferle B, Bamas C, Pezawas L, Quiner S. Dopamine- and serotonin-receptors in schizophrenia results of imaging-studies and implications for pharmacotherapy in schizophrenia. Eur Arch Psychiatry Clin Neurosci 1999 249(Suppl 4) 83—89. 

Castensson A, Emilsson L, Sundberg R, Jazin E. 2003. Decrease of serotonin receptor 2C in schizophrenia brains identified by high-resolution mRNA expression analysis. Biol Psychiatry 54 1212-1221. 

Singh AN, Barlas C, Saeedi H, Mishra RK. Effect of loxapine on peripheral dopamine-like and serotonin receptors in patients with schizophrenia. J Psychiatry Neurosci 2003 28 39-47. 

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