Inhibition of adenylyl cyclase activity

Transduction mechanism Inhibition of adenylyl cyclase stimulation of tyrosine phosphatase activity stimulation of MAP kinase activity activation of ERK inhibition of Ca2+ channel activation stimulation of Na+/H+ exchanger stimulation of AM PA/kainate glutamate channels Inhibition of forskol in-stimulated adenylyl cyclase activation of phos-phoinositide metabolism stimulation of tyrosine phosphatase activity inhibition of Ca2+ channel activation activation of K+ channel inhibition of AM PA/ kainate glutamate channels inhibition of MAP kinase activity inhibition of ERK stimulation of SHP-1 and SHP-2 Inhibition of adenylyl cyclase stimulation of phosphoinositide metabolism stimulation of tyrosine phosphatase activation of K+ channel inhibi-tion/stimulation of MAP kinase activity induction of p53 and Bax Inhibition of adenylyl cyclase stimulation of MAP kinase stimulation of p38 activation of tyrosine phosphatase stimulation of K+ channels and phospholipase A2 Inhibition of adenylyl cyclase activation/ inhibition of phosphoinositide metabolism inhibition of Ca2+ influx activation of K+ channels inhibition of MAP kinase stimulation of tyrosine phosphatase... 

Rabin RA, Winter JC. (1996b). Ibogaine and noribogaine potentiate the inhibition of adenylyl cyclase activity by opioid and 5-HT receptors. Eur J Pharmacol. 316(2-3) 343-48. 

Olianas MC, Maullu C, Onali P. 1997. Effects of clozapine on rat striatal muscarinic receptors coupled to inhibition of adenylyl cyclase activity and on the human cloned m4 receptor. Br J Pharmacol 122 401-408. 

I ) and D2 type DA receptors differ in the way they couple to the Gs0t/Goif0(- (D,) or Gi/0- (D2) intracellular G-proteins, which consequently leads to either an activation or an inhibition of adenylyl cyclase activity (Jaber et al., 1996 Sidhu and Niznik, 2000 Neve et al., 2004). 

Izenwasser S, Cote TE (1995) Inhibition of adenylyl cyclase activity by a homogeneous population of dopamine receptors selective blockade by antisera directed against Gil and/or Gi2. J Neurochem 67 1614 1621. 

Although chemokines act through specific GPCRs, chemokines relate to cytokines through many overlapping intracellular signaling pathways. One of the first signaling pathways identified was the inhibition of adenylyl cyclase activity to reduce the intracellular cAMP levels, modulated by the Ga subunit of the Gi/o proteins (Damaj et al., 1996). It was also... 

The 5-HTj receptor subset contains at least five receptor subtypes (5-HTj, 5-HTj, 5-HTjp, 5-HTjp and 5-HT ) that are linked to inhibition of adenylyl cyclase activity or to regulation of... 

The jl, 8 and k receptors are coupled, via pertussis toxin-sensitive G proteins, to inhibition of adenylyl cyclase activity, activation of receptor-linked currents, and suppression of voltagegated Ca currents. The hyperpolarization of membrane potential by K -current activation and the limiting of Ca entry by suppression of Ca currents are tenable but unproven mechanisms for explaining opioid inhibition of neurotransmitter release and pain transmission. Opioid receptors couple to an array of second-messenger systems, including activation of MAP kinases and the phospholipase C (PLC)-mediated cascade. Prolonged exposure to opioids results in adaptations at multiple levels within these signaling cascades that may relate to effects such as tolerance, sensitization, and withdrawal... 

Compounds should engage the receptor in a Gj-signaling manner leading to inhibition of adenylyl cyclase activity. 

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