Sarcosine hydrochloride

This correlation should also be applicable to the hydrochlorides of NH2" type acids, but, as in previous cases, not much information is available. Sarcosine hydrochloride again appears to be slightly abnormal in showing its carbonyl absorption at 1757 cm", but both proUne and A-phenylglycine hydrochloride absorb at 1730 cm". Histidine hydrochloride absorbs at 1706 cm" and ornithine dihydrochloride [13] at 1739 cm". As far as the limited data available allow, therefore, it seems reasonable to assume that the correlation is obeyed by this type of compound. 

Tetra-O-acetyl-D-glucosyl bromide (4.1 g.) and sarcosine ethyl ester (2.4 g.) were warmed together on a waterbath at 50° and the mixture became dark-brown. The sirup was kept at room temperature for 20 hours, whereupon crystals formed. Dry ether was added, sarcosine ester hydrochloride was removed by filtration, and the solution was quickly washed with water and dried. Removal of the ether gave a yellow sirup which, on treatment with methanol, gave needles of tetra-O-acetyl-iV-D-gluco-sylsarcosine (3.5 g., 79% yield) after recrystallization from methanol, m.p. 87-88° (no dec.). This compound was treated at 0° with methanol (100 ml.) saturated with ammonia. After removal of the solvent, crystals of A-D-glucosylsarcosine (1.7 g., 88% yield), m.p. 169-170°, were obtained. 

The l-methylimidazole-5-aldehyde is easily accessible from sarcosine methyl ester hydrochloride and dimethylamino-2-azaprop-2-en-l-... 

Sarcosine ethyl ester hydrochloride (1.0 mmol) was suspended in 1ml DMF, treated with triethylamine (1.1 equiv.) and the Step 2product (1.0 mmol), then stirred overnight. The solution was quenched with 10 ml water, then extracted three times with 10 ml chloroform, dried over Na2S04, and concentrated. The residue was coevaporated four times with ethyl alcohol and the product isolated in 95% yield as a white foam. 

A similar reaction sequence condenses iV-cyanoiminodithiocarbamic esters (7) with a-cyanoammonium salts (e.g. sarcosine nitrile sulfate) (Scheme 2.3.2). The isothiourea product (8) readily cyclizes to give 4-amino-5-cyanoimidazoles when heated with sodium ethoxide in DMF solution. It is possible to convert the dithiocarbamic esters directly into imidazoles if they are heated in DMF solution with sarcosine ethyl ester hydrochloride or methylaminoacetophenone in the presence of triethyamine [3]. These direct cyclizations arc, however, examples of both 1,2 and 1,5 bond formation. (See also Section 3.2). 

N-Methyl-N-(l-oxotetradecyl) glycine, sodium salt. See Sodium myristoyl sarcosinate Methyloxyammonium chloride. Seeo-Methylhydroxylamine hydrochloride Methyl p-oxybenzoate. See Methylparaben 2-(Methyloxycarbonylamino) benzimidazole. 

Molecular dynamics of metabolites are important for their interactions and functions. To understand the structural dependence of molecular dynamics for N-methylated glycines, Huang et al. have measured the and H spin-lattice relaxation times for sarcosine, N,N-dimethylglycine, betaine and betaine hydrochloride over a temperature range of 178-460... 

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