Saposhnikovia divaricata

The acetylene compounds - Panaxynol and falcarindiol, isolated from the roots of Saposhnikovia divaricata (Turcz.) Schischk. (Umbelliferae), selectively inhibited 5-LOX (ICso = 2 pM), leukocyte-type 12-LOX (IC50 = 1 pM), platelet-type 12-LOX (IC50 = 67 pM), and 15-LOX (IC50 = 4 pM). The same compounds had only marginal effects on COX activities with IC50 > 100 pM [126]. Bidens campylotheca Schultz Bip. ssp. campylotheca (Compositae) is a Hawaiian folk medicine for throat, stomach and asthmatic disorders. The polyacetylenes isolated from the aerial parts of the plants, such... 

Saposhnikovia divaricata (Apiaceae), Lycopersicon esculentum (Solanaceae) [leaf] (phytoalexin)... 

The roots of Saposhnikovia divaricata ("Bou-hu" in Japan and "Fang-Feng" in China) have been traditionally used as an antiphlogistic, an antipyretic and an analgesic in China and Japan. We isolated three polyacetylene compounds, i.e., falcarindiol, panaxynol and (8E)-heptadeca-l,8-dien-4,6-diyn-3,10-diol "Fig. (32)", from Saposhnikoviae Radix. As shown in "Fig. (33)", these polyacetylene compounds inhibited the formation of cyclooxygenase products HHT and TXB2dose-dependently in human platelets. 

Gui YG, Tsao R, Li L, Liu CM, Wang J, Zong XF (2011) Preparative separation of chromones in plant extract of Saposhnikovia divaricata by high-performance counter-current chromatography. J Sep Sci 34 520-526... 

Source Saposhnikovia divaricata (Turcz.) Schischk. (syn. Ledebouriella divaricata (Turcz.) Hiroe L. seseloides (Hoffm.) Wolff Siler divaricatum (Turcz.) Benth. et Hook, f.) (Family Umbelliferae or Apiaceae). 

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