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Sample Preparation for ICP-MS

An advantage of ICP-MS compared to aU other atomic mass spectrometric techniques including TIMS is that usually only simple sample preparation (e.g., by microwave induced digestion of solid samples) is necessary. Sample preparation steps for ICP-MS analyses are similar to those of ICP-OES. Concentrated solutions are analyzed after dilution with high purity water only. In order to correct mass drifts of the instrument, an internal standard element like In or Ir with known concentration (e.g., lOp-gl ) is added. The solution is then acidified with HNO3 to stabilize the metal ions in aqueous solution. [Pg.209]

Solid samples are digested with suprapure sub-boiled HNO3 to avoid contamination in an acid mixture using HF, HCl or HCIO4 (e.g., in an open vessel directly or in a closed vessel by microwave induced digestion). The sample digestion of difficult-to-dissolve sample material in closed vessels. [Pg.209]

Sample preparation also includes certain matrix separation steps (e.g., by ion exchange, extraction chromatography and others), analyte enrichment (by co-precipitation and also ion exchange, e.g., Pu separation is performed using TEVA resin ) and preconcentration steps (e.g., by evaporation of solvent) off line or on line by high performance liquid chromatography (HPLC) or capillary electrophoresis (CE) in order to improve the detection limits and avoid disturbing interference problems in ICP-MS. [Pg.211]


Jarvis, I. (1992) Sample preparation for ICP-MS. In Handbook of Inductively Coupled Plasma Mass Spectrometry (eds K. E. Jarvis, A. L. Gray, and R. S. Honk), Blackie, Glasgow, pp. 172-224. [Pg.443]

There are still a good deal of art and experience as well as science required for development of successful ICP-MS methods. A huge database of specific sample preparation and ICP-MS analysis procedures is available in the literature and should be consulted before beginning the analysis of samples. Many of the instrument manufacturers maintain databases of downloadable methods and technical reports on their web sites. Despite the low detection limits and high selectivity of ICP-MS, preconcentration or separation of sample components before analysis may be required. Numerous articles describing new analysis approaches using ICP-MS continue to be published. [Pg.125]

In order to reduce possible contamination problems during sample preparation, LA-ICP-MS is applied for the precise and accurate determination of isotope ratios at the trace and... [Pg.427]

Flow injection (FI) is a powerful front-end sampling accessory for ICP-MS that can be used for preparation, pretreatment, and delivery of the sample. Originally described by Ruzicka and Hansen, FI involves the introduction of a discrete sample... [Pg.179]

Sample preparation for analysis by hyphenated methods requires some additional planning when compared to nonhyphenated methods. All steps, extraction, concentration, and final solvent selection must take into consideration and be compatible with all the components of the hyphenated instrumentation. For gas chromatographic methods, all the components in the mixture must be in the gaseous state. For liquid chromatography (LC) or high-performance liquid chromatography (HPLC), the samples of the analytes of interest can be solids or liquids, neutral or charged molecules, or ions, but they must be in solution. If the follow-on analysis is by MS, then each of the analytes may require a different method of introduction into the MS. Metals and metal ions may be introduced by HPLC if they are in solution but commonly are introduced via AAS or inductively coupled plasma (ICP). Other analytes may be directly introduced from HPLC to MS [2],... [Pg.324]

Trace elements in human teeth and bone can be used to reconstruct dietary patterns in prehistoric populations. Several methods have been used to generate chemical data for prehistoric human bone. Among these methods INAA of solid bone and ICP-MS and ICP-ES of solutions have been used most often (33-35). With INAA, portions of bone or teeth are cleaned, sealed in vials, and irradiated to provide data for 8-10 elements. Samples analyzed by ICP-MS are digested in acid prior to analysis. In both cases, sample preparation is cumbersome. [Pg.292]

Samples were analyzed using both LA-ICP-MS and ICP-MS of solutions to assess the impact on the results of the sampling by laser ablation. For ICP-MS analysis, less than 1 mg of material was dissolved in double distilled nitric acid. SRMs BIO, B12, 51.13-4 and 71.32-4 were prepared the same way, to obtain... [Pg.343]

By the late 1990s and into the 2000s, a number of additional groups became involved in automated fluidic separations for radiochemical analysis, especially as a front end for ICP-MS. Published journal articles on fluidic separations for radio-metric or mass spectrometric detection are summarized in Tables 9.1 through 9.5. The majority of such studies have used extraction chromatographic separations, and these will be the main focus of the remainder of this chapter. Section 9.4 describes methods that combine separation and detection. Section 9.5 describes a fully automated system that combines sample preparation, separation, and detection. [Pg.524]

Sample Preparation for Speciation Analysis by Liquid-Phase Separation Techniques Coupled with ICP-MS... [Pg.509]


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