Salicylic acid azide

Hydroxybenzoyl Azide or Salicylic Acid Azide, pltlts (from eth), mp 27°, extremely volatile was prepd from salicylic acid hydrazide by action of an ice-cold soln of aq HN03 NaN02 (Refs 1 4)... 

Irreversible reaction of [18] iodine with acetylsalicylic acid, aethaverine, amidopyrine, ascorbic acid, benzo-caine, quinine, dihydrocodeine, fluorescein, glycine, hydrocortisone acetate, isoni-azid, metamizole, papaverine, paracetamol, phenacetin, phenol-phthalein, piperazine, resorcinol, salicylic acid, salicylamide, sulfaguanidine, thymol, triethanolamine, tris buffer detection by reaction chromatography... 

The cross-bridge of ASBA provides a reasonably long spacer (16.3 A). The phenyl azide portion is constructed from a salicylic acid derivative and thus possesses a ringactivating hydroxyl group. The presence of this group allows radioiodination of the ring prior to cross-linking (Chapter 8, Section 4.5). 

H)-Oxazolones are formed by the spontaneous cyclization of /3-oxo isocyanates (equation 134). Similarly, o-hydroxyphenyl isocyanate, produced by the Curtius rearrangement of the azide of salicylic acid or by the action of sodium hypochlorite on salicylamide, forms benzoxazolone (equation 135). An analogous reaction is the formation of IV-phenyl-benzoxazolone by the action of thionyl chloride on the hydroxamic acid shown in equation (136) (78TL2325). Pyrolysis of aryl azidoformates affords benzoxazolones by nitrene insertion (equation 137) (81CC241). 

The azide of salicylic acid does not provide the hydroxyindoxazene (indoxazen-3-one) on heating in benzene instead, it gives the benzo-xazolin-2-one (26) via a Curtius rearrangement.47 A similar reaction has been reported with a hexahydrosalicylic acid azide.53... 

Successive treatment of salicylic acids with ethyl chloroformate, sodium azide, and triphenylphosphine gives quite good overall yields of 1,3-benzo-xazinones (221) the intermediate imidophosphoranes (222) can be iso-lated. 3,1-Benzoxazines (223) are formed by the action of phosgeniminium... 

IODINE (7553-56-2) A powerful oxidizer. Material or vapors react violently with reducing agents, combustible materials, alkali metals, acetylene, acetaldehyde, antimony, boron, bromine pentafluoride, bromine trifluoride, calcium hydride, cesium, cesium oxide, chlorine trifluoride, copper hydride, dipropylmercury, fluoride, francium, lithium, metal acetylides, metal carbides, nickel monoxide, nitryl fluoride, perchloryl perchlorate, polyacetylene, powdered metals, rubidium, phosphorus, sodium, sodium phosphinate, sulfur, sulfur trioxide, tetraamine, trioxygen difluoride. Forms heat- or shock-sensitive compounds with ammonia, silver azide, potassium, sodium, oxygen difluoride. Incompatible with aluminum-titanium alloy, barium acetylide, ethanol, formamide, halogens, mercmic oxide, mercurous chloride, oxygen, pyridine, pyrogallic acid, salicylic acid sodium hydride, sodium salicylate, sulfides, and other materials. 

Salicylic acid resorcinalhy dr azide. 2,4-Dihydroxybenzaldehyde 2-hydroxybenzoylhydrazone [70478-94-3]... 

Kinetics and mechanisms of complex formation have been reviewed, with particular attention to the inherent Fe +aq + L vs. FeOH +aq + HL proton ambiguity. Table 11 contains a selection of rate constants and activation volumes for complex formation reactions from Fe " "aq and from FeOH +aq, illustrating the mechanistic difference between 4 for the former and 4 for the latter. Further kinetic details and discussion may be obtained from earlier publications and from those on reaction with azide, with cysteine, " with octane-and nonane-2,4-diones, with 2-acetylcyclopentanone, with fulvic acid, and with acethydroxamate and with desferrioxamine. For the last two systems the various component forward and reverse reactions were studied, with values given for k and K A/7 and A5, A/7° and A5 ° AF and AF°. Activation volumes are reported and consequences of the proton ambiguity discussed in relation to the reaction with azide. For the reactions of FeOH " aq with the salicylate and oxalate complexes d5-[Co(en)2(NH3)(sal)] ", [Co(tetraen)(sal)] " (tetraen = tetraethylenepentamine), and [Co(NH3)5(C204H)] both formation and dissociation are retarded in anionic micelles. 

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