Salicylaldehyde ethyl ether

Maltol Isobutyrate 2-Methoxy 3-(or 5- or 6-) Isopropyl Pyrazine 5H-5-Methyl-6,7 -dihydrocyclopenta[b]pyrazine 5-Methyl Furfural Methyl Furoate Methyl Hexanoate Methyl Isovalerate 5-Methyl 2-Phenyl 2-Hexenal Methyl Thiobutyrate Methyl Valerate P-Naphthyl Ethyl Ether Phenyl Ethyl Cinnamate Phenyl Ethyl Propionate Propyl Formate Propyl Mercaptan Salicylaldehyde 8-T etradecalactone 2-Tridecanone... 

Salicylic aldehyde. See Salicylaldehyde Salicylic ether Salicylic ethyl ester. See Ethyl salicylate... 

Reaction of the potassium salt of salicylaldehyde with chlo-roacetone affords first the corresponding phenolic ether aldol cyclization of the aldehyde with the ketonic side chain affords the benzofuran (1). Reduction of the carbonyl group by means of the Wolf-Kischner reaction affords 2-ethyl-benzofuran. Friedel-Crafts acylation with anisoyl chloride proceeds on the remaining unsubstituted position on the furan ring (2). The methyl ether is then cleaved by means of pyridine hydrochloride (3). lodina-tion of the phenol is accomplished by means of an alkaline solution of iodine and potassium iodide. There is thus obtained benziodarone (4)... 

An equimolar mixture of the crude amino alcohol and salicylaldehyde in toluene was heated under reflux for 2 h. Evaporation of the toluene followed by distillation of butyl fert-butylphenyl ether (bp 100 C/3 torr) gave the corresponding Schiff base as a yellow viscous residue. The yield was estimated to be 65% (LC) based on phenylalanine ethyl ester. A pure sample, [a]j3 -8.00 ° (c 1.00,chloroform), was isolated by column chromatography on silica gel [36]. 

Salcare SC 10. See Polyquaternium-7 Salcare SC 30. See Polyquaternium-6 Salcare SC 90. See Steareth-10 allyl ether/acrylates copolymer Sal chalybis. See Ferrous sulfate anhydrous Sal ethyl. See Ethyl salicylate Salicylal. See Salicylaldehyde Salicylaldehyde... 

Reaction Procedure (Scheme 3.2) In a 25 ml round-bottomed flask equipped with a reflux condenser under N2 were placed salicylaldehyde (1 mmol) and 1,2-dibromobenzene (2 mmol), K2CO3 (2 mmol), (PPh3)2PdCl2 (35 mg, 0.05 mmol) and 5 ml DMF. The mfacture was heated to 130 °C for 12 hours before it was cooled to room temperature. The reaction mixture was diluted with diethyl ether (25 mL) and washed with water and brine. The aqueous layer was extracted with diethyl ether (3x25 mL). The organic layers were combined and dried with MgS04, filtered, and the solvent was removed under reduced pressure. The residue was purified by flash chromatography on silica gel (petroleum ether-ethyl acetate, 50 1) to afford the desired product. 

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