Salicyl purple

Reactions of Aspirin, (i) Distinction from Salicylic acid. Shake up with water in two clean test-tubes a few crystals of a) salicylic acid, (0) aspirin, a very dilute aqueous solution of each substance being thus obtained. Note that the addition of i drop of ferric chloride solution to (a) gives an immediate purple coloration, due to the free —OH group, whereas (b) gives no coloration if the aspirin is pure. 

Willow bark (weidenrinde, white willow, purple osier willow, crack willow) S lixalba, purpurea, fragilis Analgesic Adverse reactions are those associated with the salicylates Do not use with aspirin or other NSAIDs. Do not use in patients with peptic ulcers and other medical conditions in which the salicylates are contraindicated. 

He then added a FeCl3-KCl-HCl solution to create a purple salicylate complex. He then diluted this solution to 250. mL with distilled water. Determine the molarity of the stock solution. 

If any salicylic acid remains unreacted, its presence can be detected with a 1% iron(III) chloride solution. Salicylic acid has a phenol group in the molecule. The iron(III) chloride gives a violet color with any molecule possessing a phenol group (see Experiment 30). Notice the aspirin no longer has the phenol group. Thus a pure sample of aspirin will not give a purple color with 1% iron(III) chloride solution. 

Compare and record your observations. The formation of a purple color indicates the presence of salicylic acid. The intensity of the color qualitatively tells how much salicylic acid is present. 

To analyze the purity of the ASA he produced, the student measured out 0.400 g of pure, analytical reagent grade ASA and then treated it with NaOH to create sodium salicylate. He then added a FeCl3-KCl-HCl solution to create a purple salicylate complex. He then diluted this solution to 250. mL with distilled water. Determine the molarity of the stock solution. 

A rapid method (31) for the determination of salicylate in biological fluids is presented, based on a reagent containing ferric nitrate, mercuric chloride and hydrochloric acid, which precipitates the proteins and simultaneously reacts with salicylic acid to give a purple color. 

In the salicylic add treatment cases discussed above Norit PAC 20B, Norit E Supra USP and Norit SX2 performed better then the other activated carbons in the removal of TOC, while Darco KB and Hydrodarco C had the worst performance. Hydrodarco C also mtroduced a purple color into the filtrates at low carbon dost es. 

Metacresol purple. See m-Cresol purple Metacure T-1. See Dibutyltin diacetate Metacur T-9. See Stannous octoate Metacurd T-12. See Dibutyltin dilaurate Metadelphene. See Diethyl toluamide Metaformaldehyde. SeeTrioxane Metahomomenthyl salicylate. See Homosalate Metalaxil. SeeMetalaxyl Metalaxyl... 

If we use a salicylate, such as sodium salicylate, in place of a taniiatc, a bcautifiil purple colour is the result, which can be reacted upon or cleared as before. 

Dodge and Shemdal have recently shown that cassia oil yields at least 0 5 per cent, of constituents removable by shaking out with 2 per cent, sodium hydroxide solution. The oily liquid obtained by liberating these alkali-soluble constituents in the usual manner was found to consist of approximately 25 per cent, of salicylic aldehyde 60 per cent, of ooumarin from 8 to 10 per cent, of cinnamic acid with small amounts of salicylic and benzoic acids, and of a liquid acid not yet identified. Although the amounts of salicylic aldehyde and of coumarin are small, they are sufficient to contribute to the composite aroma of the oil. In fact, the presence of salicylic aldehyde may be detected, by odour alone in the first fractions of the redistill oil. It is to this constituent that the purple colour reaction is due, which is obtained when cassia oil is shaken with dilute alkali and the acidified aqueous portion is treated with ferric chloride. 

The Ferric Chloride Phenol Test. —Many phenols give typical blue, green, purple, or red colors when a drop of ferric chloride is added to a dilute aqueous solution of the unknown. A number of phenols which do not give this test readily are found to respond when tested in alcoholic solution. Among the carboxy derivatives of phenol, those having the carboxyl group ortho to the phenolic hydroxyl, as in salicylic acid, respond with a typical deep purple color, but many compounds with the carboxyl group in the meta or para position fail to respond to the test. 

Iron Test for Acetoacetic Acid.— Add dilute (1 per cent.) ferric chloride drop by drop to 5 ml. of urine until the buff-coloured precipitate of ferric phosphate, which is given by all specimens of urine, ceases to form. Further addition of the ferric chloride now produces a brown-purple colour if the urine contains more than 0-07 per cent, acetoacetic acid. Urines after administration of salicylates, aspirin, and related drugs, give a violet colour on addition of ferric chloride, which may be mistaken for an acetoacetic acid reaction. 

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