Saframycin alkaloids

For a synthetic example using a Manich reaction for saframycin alkaloids, see Zhou, B. Guo, J. Danishefsky. S.J. Tetrahedron Lett., 2000, 41, 2043. 

Saframycin belongs to a family of complex polycyclic alkaloids endowed with spectacular antiproliferative activity. The successful demonstration that analogues of the natural product are clinically effective for the treatment of solid tumors has stimulated intense efforts towards the total synthesis and medicinal chemistry of these alkaloids. Myers and Lanman adapted their solution phase synthesis of saframycin to a ten-step solid phase synthesis, leading to the preparation of 16 analogues [40]. The key steps are two Pictet-Spengler reactions, which are used... 

Synthesis of antitumor bis-tetrahydroisoquinoline alkaloids, saframycins and ecteinascidins 05CJO42. 

Synthetic Studies Toward Saframycin B and Ecteinascidin 743 (Yondelis) Tetrahy-droisoquinoline alkaloids are a broad family of biologically active natural products. Takemoto et al. [39] have carried out a concise synthesis of the CDF ring system present in this kind of alkaloids (Scheme 2.36). Both An(I)-catalyzed intramolecnlar hydroamination of alkynyl amide and NBS-mediated oxidative FC cyclization were utilized as key reactions. By rednctive alkylation of a-amino acid derivative 235 with aldehyde 236, the conpling prodnct 237 was obtained... 

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