Safety performance rating scale

A number of behavioral ratings scales and psychometric and performance tests, listed in Tables 20.16 to 20.18, are briefly summarized below, since many of these scales and tests may be used to evaluate safety as well as efficacy. The following comments on the tests provide only a few highlights readers who are interested in more details are advised to obtain additional information before choosing the tests that appear most relevant to be included in their particular protocol. 

In a double-blind, parallel-group study, Bondareff et id. (2000) compared the SSRI sertraline and the tricyclic compound nortriptyline with regard to their efficacy and safety in a group of 210 outpatients 60 years and older. The patients met the DSM-DI-R criteria for major depressive episode and had a minimum score of 18 on the Hamilton Rating Scale for Depression. Their mean age was about 68 years, most patients were white and about 60% were female the severity of depression was rated as moderate in more than 70% and as severe in more than 20% of the cases. The daily doses of sertraline were between 50 and 150 mg, and those of nortriptyline were 25 100 mg the treatment lasted 12 weeks. In addition to clinical rating scales and self-assessment instruments, patients took the following tests of cognitive performance ... 

Various aspects of the effect of process scale-up on the safety of batch reactors have been discussed by Gygax [7], who presents methods to assess thermal runaway. Shukla and Pushpavanam [8] present parametric sensitivy and safety results for three exothermic systems modeled using pseudohomogenous rate expressions from the literature. Caygill et al. [9] identify the common factors that cause a reduction in performance on scale-up. They present results of a survey of pharmaceutical and fine chemicals companies indicating that problems with mixing and heat transfer are commonly experienced with large-scale reactors. 

Performance shaping factor (PSF) rating (scale of 0-10) and weightage (lo, med, hi) PSP is influenced by work force deployment, safety culture, behavioral safety. 

For inqiroved safety performance, a form should be developed, listing the six items previously noted with a rating scale for the supervisor on each of those tasks. The portion of the merit increase determined by safety performance should be in the range of 10 to 20 percent. Arriving at a feiir and honest evaluation of the supervisor can be made easier by using the form in Figure 2-1. 

The PVdF—HFP separators used in PLION cells were around 3 mil thick, and had poor mechanical properties. It has been reported that the major source of rate limitation in PLION cells was the separator thickness. The rate capability of these cells can be significantly improved by decreasing the separator thickness to that typically used in liquid electrolyte system. Moreover, in the absence of shutdown function. the separator does not contribute to cell safety in any way. Park et al. reported that the HFP content in separators did not have any significant impact on cell performance. The Bellcore process has proven to be an elegant laboratory process but is difficult to implement in large-scale production. 

Figure 6.16 Substitution example reaction performed in a reaction calorimeter in the temperature controlled mode, described in Figure 6.12. The left scale represents the heat release rate (Wkg ) and the temperatures (°C). The right scale represents the conversion. The safety data evaluations are the heat of reaction, specific heat capacity, conversion and T,f as a function of time.

The adsorption of gaseous iodine species on surfaces has received much attention in the reactor safety literature. Varieties of metal, concrete and painted surfaces are in a reactor containment building. The gaseous forms of iodine will interact with these surfaces. The interactions are usually thought to involve a rapid physical adsorption followed by a slower chemical reaction. Dry (or moist, but not wet) surfaces of both stainless steel and organic (vinyl-, epoxy-, polyurethane-) paint have large capacities for absorbing molecular iodine. The adsorption rate of molecular iodine on the dry surfaces is close to the limit dictated by gas-phase mass transport. Intermediate-scale studies performed in the Radioiodine Test Facility have shown that about 75 to 95% of airborne molecular... 

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