Saccharomyces cerevisiae transcriptional activation

M. Jacquet, G. Renault, S. Lallet, J. De Mey, A. Goldbeter, Oscillatory nucleocytoplasmic shuttling of the general stress response transcriptional activators Msn2 and Msn4 in Saccharomyces cerevisiae. J. Cell Biol. 161, 497-505 (2003). 

Human Set9 is a 50 kDa H3 methyltransferase that methylates Lys-4 of H3. The enzyme methylated free H3 but not H3 in chromatin substrates. There is evidence that Set9 may stimulate activated transcription [198]. Set9 has the SET domain but lacks the cysteine-rich (pre-SET and post-SET) domains. Disruption of Saccharomyces cerevisiae and Saccharomyces pombe Setl obliterates H3 methyl Lys-4 [199]. Thus this SET domain containing protein appears to be a H3 Lys-4 methyltransferase, catalyzing both di- and tri-methylation of H3 Lys-4 [155]. However, studies with recombinant Setl failed to show histone methyltransferase activity. It has been suggested that other associated proteins may be required for the Setl to be catalytically active [139,200]. Indeed, Setl is associated with several... 

Muchardt, C. and Yaniv, M. (1993) A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor. EMBO J. 12, 4279 290. 

Donald, R.G.K., Schindler, U., Batschauer, A. Cashmore, A.R. (1990). The plant G-box promoter sequence activates transcription in Saccharomyces cerevisiae and is bound in vitro by a yeast activity similar to GBF, the plant G-box binding factor. The EMBO Journal 9, 1727-35. 

Fig. 3. Mad activates the expression of three gene products involved in high-affinity copper ion uptake in Saccharomyces cerevisiae. Two genes encode Cu ion permeases Ctrl and Ctr3. The third is one of two metalloreductases that reduce Cu(II) ions prior to uptake. Mad is a transcriptional activator in Cu-deficient yeast cells.

Dietz, M., Heyken, W.T., Hoppen, J., Geburtig, S., and Schuller, H.J., 2003, TFIIB and subunits of the SAGA complex are involved in transcriptional activation of phospholipid biosynthetic genes by the regulatory protein Ino2 in the yeast Saccharomyces cerevisiae. Mol. Microbiol. 48 1119-1130. 

Lamping, E., Paltauf, F., Henry, S.A., and Kohlwein, S.D., 1995, Isolation and characterization of a mutant of Saccharomyces cerevisiae with pleiotropic deficiencies in transcriptional activation and repression. Genetics 137 55-65. 

Schwank, S., Ebbert, R., Rautenstrauss, K., Schweizer, E., and Schuller, H.-J., 1995, Yeast transcriptional activator IN02 interacts as an Ino2p/Ino4p basic helix-loop-helix heteromeric complex with the inositol/choline-responsive element necessary for expression of phospholipid biosynthetic genes in Saccharomyces cerevisiae. Nucleic Acids Res. 23 230-237. 

Schuller. C.. Mamnun, Y.M., Wolfger, H., Rockwell. N.. Thorner, J., and Kuchler, K. (2007) Membrane-active compounds activate the transcription factors Pdrl and Pdr3 connecting pleiotropic drug resistance and membrane lipid homeostasis in Saccharomyces cerevisiae. Molecular Biology of the Cell, 18, 4932-4944. 

Sidorova, M., Drobna, E., Dzugasova, V., Hikkel, 1., and Subik, J. (2007) Loss-of-function pdr3 mutations convert the Pdrlp transcription activator to a protein suppressing multidrug resistance in Saccharomyces cerevisiae. FEMS Yeast Research, 7, 254-264. 

Ulaszewski, S., Ramotar, D., and Tamas, M.J. (2004) Transcriptional activation of metalloid tolerance genes in Saccharomyces cerevisiae requires the AP-l-like proteins Yaplp and YapSp. Molecular Biology of the Cell, 15. 2049-2060. 

Marchler, G., Schuller, C., Adam, G., and Ruis, H. 1993. A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions. EMBO J. 12, 1997-2003. 

Rmt1 Saccharomyces cerevisiae PRMT1 H4 R3 39,786 5.23 Transcriptional activation... 

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