S glabra

Stephania rotunda Lour. (S. glabra Miers) (Memispermaceae)... 

In some species, pharmacological effects other than muscle-relaxation may dominate. Thus, as already seen, the activity of S. erichsonii extracts appears to be due primarily to the presence of diaboline derivatives. Leaf extracts have analgesic properties, while stem-bark extracts have spasmolytic properties and augment the activity of the central nervous system (50). The bark alkaloids of S. glabra are reported to have central rather than peripheral effects (Table 1.4, footnote j). Sublethal doses of aqueous extracts from S. castelnaeana cause hypertension, tachycardia, and slight respiratory stimulation enhancement of the hypertension by atropine and its reduction by hexamethonium (mecamylamine) show that the extract has nicotinic activity. Evidently, the toxicity of the plant must be partly due to the tertiary bases it contains (314). 

Floriani has recently examined bark from Aspidosperma quebracho bianco Schlecht f. pendulas Speg, in which he found the known alkaloids, quebrachine (yohimbine) and aspidospermine, as well as Hesse s aspidosamine, C2gH2g02N2, and a new base, aspidospermicine, Ci Hj ON, l-SHjO (1938). Hartmann and Schlittler have shown that the alkaloid vallesine from Vallesia glabra (Apocynaceae) is aspidospermine, and this has been confirmed by Deulofeu et aJ. who have also found it in V. dichotoma. Later Schlittler and Rottenberg by chromatographic analysis of the mother liquors of aspidospermine isolated a second alkaloid for which they used the old name Vallesine (1948). ... 

Heuer, S. et al., Betacyanins from bracts of Bougainvillea glabra. Phytochemistry, 37, 761, 1994. 

Malik, S.B., Sharma, P., and Seshadri, T., Furanoflavonoids from leaves of Pongamia glabra, Indian J. Chem., 15B, 536, 1977. 

Aloe barbadensis, A. vera Silene ocaulis, S. virginica Glycyrrhiza glabra Jasaminum grandiflorum, J. officinale Impatiens balsamina... 

Mootoo, B. S., Ransawan, R., Khan, A. et al. (1996). Tritetranorterpenoids from Raugea glabra. Journal of Natural Products 59 544-547. 

There is considerable interest in understanding the structural bases for these differences because this information would be very useful in designing steroids and other compounds to selectively regulate the activity of one or more steroid dehydrogenases as a means of treating hormone-responsive diseases. There is precedent for this kind of treatment in the use of licorice extract from the root of the plant Glycyrrhiza glabra [15,27] to treat Addison s disease,... 

Heuer, S., Richter, S., Metzger, J.W., Wray, V., Nimtz, M. and Strack, D. (1994) Beta-cyanins from bracts of Bougainvillea glabra. Phytochemistry, 37, 761-7. 

Cytisus scoparius (Scotch broom) D/jpferyx species (tonka beans) Genista tinctoria (dyer s broom) Glycyrrhiza glabra (liquorice)... 

Ginkgo biloba (maidenhair) Glycyrrhiza glabra (liquorice) Gossypium (cotton) Harpagophytum procumbens (devil s claw)... 

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