Run-in period

These changes occur during what is referred to as the run-in period. Once run-in, the slack on the new belts must be taken up to eliminate slippage, burning, or other irreparable damage. The following are common sense rules of V-belt tensioning ... 

As an extra safeguard, on new compressors a fabric liner may be fitted inside the mesh strainer to catch fine dirt which will be present. Such liners must be removed at the end of the running-in period, as they create a high resistance to gas flow. 

RT-ILs are also selected as lubricant additives. Usage of ionic liquids as boundary lubricant additives for water has resulted in dramatically reduced running-in periods for silicon nitride materials [70]. When ILs were mixed into a neat mineral oil, the mixture has proven to produce lower wear on aluminum flat than either the oil or the ionic liquid alone [72], which indicates that a small amount of ILs in the mineral oil may function as an anti-wear additive. 

Fortunately, there is a methodological feature of these clinical trials that makes the charge of falsifying the initial data somewhat less problematic than it might otherwise be - as long as those are the only data that were fudged. All of the trials we analysed had what is called a placebo run-in or wash-out phase. The way this works is as follows. After people are assessed for inclusion in the trial, they are all given a placebo for a week or two. After this run-in period, the patients are reassessed, and anyone who has improved is excluded from the trial. The baseline severity scores that we used in our analyses were those taken after the placebo... 

Quitkin, Frederic M., Patrick J. McGrath, Jonathan W. Stewart, Katja Ocepek-Welikson, Bonnie P. Taylor, Edward Nunes, Deborah Delivannides, Vito Agosti, Steven J. Donovan, Donald Ross, Eva Petkova and Donald F. Klein, Placebo Run-in Period in Studies of Depressive Disorders Clinical, Heuristic and Research Implications , British Journal of Psychiatry 173 (1998) 242-48... 

For both the DuPont and Akron procedures, the standard specifies a trial run to establish the level of abrasion rate and a running in period before the... 

In a multicenter, double-blind, placebo-controlled study, 81 patients, in whom treatment with metformin was inadequate, received extra acarbose or placebo during 24 weeks after a 4-week run-in period to establish the optimal dose of acarbose (28). HbAic was reduced by 1.02% and fasting blood glucose by 1.13 mmol/1. Gastrointestinal adverse effects were more common in the acarbose group. 

In 303 patients who took placebo or rosiglitazone for 8 weeks after a run-in period, rosiglitazone 4 mg bd had the same effect as 6 mg bd, but hemoglobin and hematocrit were lower with 6 mg bd (101). In another study troglita-zone produced small reductions in hemoglobin, hematocrit, and erythrocyte counts and increases in lactate dehydrogenase and blood urea nitrogen (102). 

Ahmed S, Dack C, Farace G, Rigby G, Vadgama P. Tissue implanted glucose needle electrodes early sensor stabilisation and achievement of tissue-blood correlation during the run in period. Analytica Chimica Acta 2005, 537, 153-161. 

Tamura et a/.87 have shown that the loss of activity occurring during the run-in period of commercial catalysts is unavoidable. Bazarova et al.50 conclude that the composition of the active component is very complex and depends upon that of the reaction mixture. This means that the catalyst composition is not constant over the length of the reactor, making kinetic... 

Three cannabis-based medicinal extracts in sublingual form recently became available for use against pain. In a randomized, double-blind, placebo-controlled, crossover study for 12 weeks in 34 patients with chronic neuropathic pain THC extracts were effective in symptom control (59). Drowsiness and euphoria/dysphoria were common in the first 2 weeks. Dizziness was less of a problem. Anxiety and panic were infrequent but occurred during the run-in period. Dry mouth was the most common complaint. 

Exclusion of patients who experienced adverse effects during a run-in period... 

Reporting of adverse effects of treatment in trials and systematic reviews is often poor. In a review of 192 pharmaceutical trials, less then a third had adequate reporting of adverse clinical events or laboratory toxicology (loannidis and Contopoulos-Ioannidis 1998). Treatment discontinuation rates provide some guide to tolerability but pharmaceutical trials often use eligibility criteria and run-in periods to exclude patients who might be prone to adverse effects. 

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