Run failures

Low notch toughness high notch sensitivity rapid, running failures below DBT. 

Start failures predominantly on instrumentation. Running failures on seals, bearings, drive components and instruments. 

The process should be requalified when production line is not in operation for 3 months. In case of one run failure, three consecutive runs should be performed. 

Note that the unprotected circuits of the control had substantial drift of the three that did not fail during the test run. Failures were evident upon inspection of the part as occurring from disintegrated resistors. Dip coated PSS and HMDS had fewer failures and less drift. The best protection from moisture was offered by the plasma-polymerized HMDS. The indicated 1.7% drift is close to the acceptable limits of the design for power-on thermal aging effects. 

From the analyst s viewpoint, the more demanding the acceptance criteria, the higher the risk of run failure the severity of these problems increases with the number of compounds to be analyzed by a given method, since failure to meet the established run acceptance criteria for... 

The amount of available sample needs to be considered both from the perspective of how this impacts the method and LLOQ and also from the standpoint of having enough sample for re-analysis in the event of run failure or other sample re-assay directives. Even in cases where an adequate amount of sample is available for re-assay, repeated run failures could lead to depletion of the sample. This is particularly problematic with multi-analyte assays where the probability of run failure due to one or more of the analytes in the assay increases as a function of the number of analytes in the method (Dadgar 1995). 

In some instances laboratory contamination may occur but not be detected in the blanks that are run concurrently with analytical samples. This situation is often discovered via unusually high concentrations of analyte detected in the standards or quality control samples at the lower end of the curve. This relatively common indicator is often overlooked until the problem is so bad that the incidence of run failures increases significantly. 

If a validation run fails for any other reason, the data should still be processed and included in the vahdation report (Section 10.3.4). If the validation fails repeatedly, the method notebooks and procedures should be reviewed to ensure that it is being run correctly. If there is no apparent reason for the run failures, it will be necessary to perform additional method development experiments, modify the method and re-start the validation. Under no circumstances should the method be modified between vahdation runs. 

If the analytical method goes out of control, e.g. as indicated by the control chart maintained for the QCs (Section 2.5.3) repeated run failures without cause, or loss of selectivity... 

Fuel Cycle 2. Demands by Surveillance Tests (ST) 3. Start Failures 4. Run Failures 5. Probability of Failure (total) 6. Reliability 7. Maintenance Rule Category 8. Total values considering Cycle-1 to Cycle-8 period. 

Two Brayton System (2 Running) Failure Rate % change in System Reliability due to an increase in component reliability by the ftiilure rate % change in System Reliability due to a decrease in component reliability by the failure rate... 

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