Roth, Bruce

Invented by Bruce Roth in the late 1980s and now sold by Pfizer, the anticholesterol drug Lipitor became the world s best-selling drug. This article tells the story of the drug s development and success. 

Contemporary Drug Synthesis. Jie-Jack Li, Douglas S, Johnson, Drago R. Sliskovic, Bruce D. Roth Copyright 2004 John Wiley Sons, Inc. 

Bruce W, Folkerts O, Garnaat C, Crasta O, Roth B, Bowen B (2000) Plant Cell 12 65... 

Jie Jack Li Douglas S. Johnson Drago R. Sliskovic Bruce D. Roth... 

THE DRUG SHOWN HERE IS ATORVASTATIN, better known by its trade name Lipitor . it is a member of a ciass of pharmaceuticais caiied statins, which iower biood choiesteroi ieveis, thereby reducing the risk of heart attacks and strokes. Lipitor was first synthesized in 1985 by Bruce Roth of Warner-Lambert/Parke Davis (now part of Pfizer) and was approved for use in 1996. it is the best-seiiing drug in pharmaceuticai history, with saies of more than 125 biiiion from 1997 to 2011. it became avaiiabie as a generic drug in 2011. 

Jie-JackLi, Douglas Johnson, Drago Sliskovic, Bruce Roth. Contemporary Drug Synthesis. New York Wiley 2004 22-23. 

Chauhan, A., Turchan, J., Pocemich, C., Bruce-Keller, A., Roth, S., Butterfield, D.A., Mqor, E.O. and Nath, A., Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transport. J. Biol. Chem., 278, 13512-13519 (2003). 

TungLe Edward Lenoir Rick McCabe Ken Mennen Alan Millar Brian Moon Lyle Mulder TomNanninga Tim Puls Bruce Roth Klaus Steiner Brian Swierenga Robert Wade JimWen le Joachim Witzke Jim Zeller... 

Bruce, W., Folkerts, O., Garnaat, C., Crasta, 0., Roth, B., and Bowen, B. (2000). Expression Profiling of the Maize Flavonoid Pathwey Genes Controlled by Estradiol-Inducible Transcription Factors CRC and P, The Plant Cell, 12, 65—79. 

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