Rose, Aaron

Aaron Ciechanover, Avram Hershko, Irwin Rose... 

Ubiquitin is a small but highly conserved protein found exclusively in eukaryotes. The characteristics of this protein were established in the early 1980s. For this monumental work, Aaron Ciechanover, Avram Hersko, and Irwin Rose shared the Nobel Prize in Chemistry in 2004. 

The North entrance of Chartres Cathedral, beneath the rose window, is the Gate of the Initiates. Melchizedek, Aaron, Aima the Mother of Mary, David and Solomon welcome the Initiates there (cl235). Statues in stone of Melchizedek, Abraham and Isaac, and Moses also welcome visitors through the Central Portal of the North Transept (cl215). 

The ubiquitin-mediated degradation of intracellular proteins is a universal phenomenon in eukaryotic cells that is fundamental to the regulation of various cell processes. In 2004, Aaron Ciechanover, Avram Hershko, and Irwin Rose shared the Nobel Prize in chemistry for their discovery of this pathway. 

Aaron Ciechanover (Israel), Avram Hershko (Israel), and Irwin Rose (United States) for the discovery of ubiquitin-mediated protein degradation. While the overwhelming majority of biochemical research on proteins has focused on how they are synthesized and how they function, these three researchers took a unique path and studied how cells regulate their breakdown. They discovered that proteins are broken down (and rebuilt) at a much faster rate than anyone probably would have expected. Proteins are labeled when it is time for them to be broken down, and then they are chopped up into small pieces so that they no longer function. 

Aaron Rose. The Quotations Page available at htlp //www.quotations page.com/quotes/Aaron Rose/ (accessed September 20, 2009). 

Aaron Ciechanover, Avram Hershko, Irwin Rose 1946 James B. Sumner, John H. Northrop, Wendell M. Stanley... 

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