Roller compaction slugging process

In the third country, roller compaction was substituted for the slugging process. While the sizing of the slugs and compacts were completed on different machines, and the particle size results were not exactly the same in each situation, the tablet content uniformity results were equivalent. Content uniformity relative standard deviations of 1.5-2.0% ( = 10 tablets) were routinely achieved. The tablet dissolution profiles averaged 95% or higher within 30 minutes in each country. 

A number of these attributes, best technology practices and features, were rated for their industrial and pharmaceutical importance and reported by Miller and Sheskey in 2001. Ultimately, today s roller compaction technology offers a continuous process with better process controls, manufacturing efficiencies, and environmental protection than an archaic slugging process technology. 

---