Rohm Pharma

Rohm Pharma Eudragit LlOO Technical Bulletin Info E-4/e (May 1989). 

Jalonac (Rohm Pharma)- Nardy (Vemin)-comb. Tuinal (Flynn)-comb. 

Jatropur (Rohm Pharma) Prestole (Pharmafarm)- Tricilone (Vangard)-comb. 

Eudragit RS 100, RSPM, S 100 and L 100 were received by courtesy of Rohm Pharma GmbH, Darmstadt, FRG. Theophylline (Indian Pharmacopoeia), polyisobutadiene, acetone, trichloroethylene, cyclohexane and methylene chloride were procured commercially. 

Eudragit (Rohm/Pharma Polymers, Darmstadt, Germany) is a class of polymer that will dissolve at specific pH values. Eudragit polymers are members of the poly(alkyl methacrylate) family of polymers. This family of polymers has a wide degree of properties due to the many modifications used in the formation of the polymers. The dissolution properties are based on the modification of the carboxylic moieties of methacrylic acid. The degree of modification and the specific modification determine at what pH and how quickly the polymers dissolve. 

Jalonac (Rohm Pharma)-comb. wfm Metrotonin (Temmler)-comb. wfm... 

D Ornatos (Rohm Pharma)- GB Stelabid (S.K.F.)-comb. USA Combid (Smith Kline ... 

D Sarenin (Rohm Pharma) USA Sarenin (Norwich Pharm.) ... 

Jatropur (ROhm Pharma) Jenateren (Jenapharm)-comb. 

Lehmann, K. Rothgang, G. Bossier, H. Dreher, D. Petereit, H.U. Liddiard, C. Weisbrod, W. Practical Course in Lacquer Coating Rohm Pharma, GmbH Weiterstadt, 1989. 

Rohm Pharma GmbH. Eudraglt. http //www.roehm.com/en/ pharmapolymers (accessed 20 May 2005). 

The commercial supply is primarily derived from expressing the enzyme Penicillin G amidohydrolase (E.C. 3.5.1.11) ATCC 9637 in E. coli. Soluble enzyme was obtained from Calbiochem and Boehringer-Mannheim, and immobilized enzyme was obtained from Sigma, Rohm-Pharma and Boehringer-Mannheim. The recovery of the immobilized enzyme made it cost effective compared with the soluble enzyme. 

In order to determine the optimum concentration of the acylating agent, phenyl-acetic acid, the amount of amine (0.47 mmol) and enzyme PGA (3.16 units, Rohm-Pharma) were kept constant and the acylating agent was varied from 0.125 to 1.5 mmol (17 mg to 204 mg) (Fig. 9). 

A minimum amount of enzyme and high turnover are necessary for a cost-effective operation. The amount of the racemic amine ( 100 mg), phenylacetic acid (193 mg) and reaction volume (10 mL) were kept constant at pH 6. Water was used as the reaction medium. The amount of immobilized enzyme was varied from 0.8 to 80 units (5 mg to 50 mg) (Rohm-Pharma). The reaction was carried out for 16 hours at room temperature (Fig. 10). 

Uses Thickener for coating, nip-padding, and printing compds. coatings for pharmaceutical therapeutic proteins Manuf./Distrib. Degussa Rohm Pharma Trade Names Rohagit SD15... 

Add PAH immobilized on acrylic beads (Eupergit-PcA Rohm Pharma, Weiterstad, Germany) (1 EU/pmol of Phacm), and monitor the reaction by HPLC. 

The polymers used were polyvinylchloride (Sicron 230, Montedison, Italy) vinylchloride/vinylacetate copolymer (Sicron 822, Montedison, Italy) polytetrafluoroethylene (Fluon, I C.I, U.K ) polyethylene (Montedison,Italy) acrylic polymer (Paraloid K 120 N, Rohm Haas, Italy) acrylic/methacrylic acid esters copolymer with 10 % of quaternary ammonium groups (Eudragit RL, Rohm Pharma, Germany) and with S % of these groups (Eudragit RS, Rohm Pharma, Germany) ... 

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