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Eudragit polymers

The solvent evaporation method resulted in the production of LS characterized by a smaller size (20 pm mean diameter) but poor mechanical properties in respect to particles with the same composition that were obtained by the melt dispersion technique (170 pm mean diameter). The use of a combination of lipids and a methacrylic polymer (Eudragit RSI00) overcame this problem, resulting in the production of spherical particles with a narrower size distribution and good mechanical properties [53,56],... [Pg.6]

The covalent coupling of a serine protease to a soluble-insoluble polymer (Eudragit) is also accomplished using a water soluble carbodiimide. Mycotoxins in foods often contain carboxyl groups suitable for carbodiimide mediated coupling with amino groups in proteins useful for developing immunoassay methods. " ... [Pg.267]

In order to overcome the disadvantage of hydrophilic matrices of uncontrollable erosion of the hydrated polymer gel on the tablet surface, a combined polymer-wax carrier material was evaluated by Huang et al. Carnauba wax was combined with the enteric acrylic polymer, Eudragit LlOO, and investigated as a carrier... [Pg.4069]

Figure 5 In vitro dissolution profile of different dosage forms at pH 6.8, simulating the small intestine. Dosage forms that are film coated with an enteric polymer, EUDRAGIT L, (SalofaUc, Claversal), show a delay in drug release at the dissolution pH of the polymer, which is probably due to the higher amounts of polymer that are applied (Rudolph et al., in press). Other film coatings Pentasa (Ethylcellulose), Ascacohtin (EUDRAGIT S 100). Figure 5 In vitro dissolution profile of different dosage forms at pH 6.8, simulating the small intestine. Dosage forms that are film coated with an enteric polymer, EUDRAGIT L, (SalofaUc, Claversal), show a delay in drug release at the dissolution pH of the polymer, which is probably due to the higher amounts of polymer that are applied (Rudolph et al., in press). Other film coatings Pentasa (Ethylcellulose), Ascacohtin (EUDRAGIT S 100).
Ashford and colleagues (54) showed that pH-sensitive polymers (Eudragit) are not effective for colon-targeted drug... [Pg.140]

The release of two chiral drugs, ketoprofen and ricobendazole, from matrix tablets that are produced with two different excipients (a chiral cellulose polymer, HPMC, and an achiral acrylic polymer, Eudragit RL) was investigated by Alvarez et al. [31]. In the case of ketoprofen from... [Pg.64]

In another example of a hybrid DDS, ranitidine hydrochloride, the H2 histamine receptor inhibitor, was intercalated in MMT and coated with the cationic polymer Eudragit ElOO using an oil-in-water solvent evaporation method. The material obtained had the form of microparticles. It vras found that in the presence of Eudragit ElOO, both the release rate and the amount of drug released noticeably increased, because of the effective exchange of the polycation with intercalated drug molecules. In a similar... [Pg.310]

The most commonly used polymers for the MBP process are HPMCAS (L, M, and H grades) and polymethacrylate-based polymers, e.g., Eudragit LlOO, LlOO-55, and S100. Other ionic polymers such as cellulose acetate phthalate (CAP), hypromellose phthalate (HP), polyvinyl acetate phthalate (PVAP), and cationic polymer Eudragit El00 can also be used. The polymer use levels are determined based on the drug loading and amorphous form stability. [Pg.332]

Zhang, Y., Xu, J. L., Yuan, Z. H., Xu, H. J. and Yu, Q. (2010). Artificial neural network-genetic algorithm based optimization for the immobilization of cellulase on the smart polymer Eudragit L-100. Bioresource Technology, 101,3153-3158. [Pg.436]

Gupta MN, Guoqiang D, Kaul R et al. Purification of xylanase from trichoderma viride by precipitation with an anionic polymer Eudragit S 100. Biotechnol Tech 1994 8(2) 117-122. [Pg.57]

New formulations of polymeric and Upid nanoparticles are currently in development. The non-biodegradable positively-charged polymer Eudragit RS 100 and semi-solid lipid excipient Gelucire 44/14 were used as a vehicle, the cationic lipid octadecylamine was used as a cationic agent obtaining successfully a pilocarpine HCl system for ocular application [137]. [Pg.167]

The physical states of the substances modeled differ at 298.15 K DSC measurements (see also Section 16.2.3.2) show that polymer Eudragit RS is amorphous without crystalline sections. In contrast, the plasticizers TEC, ATBC, and DBS are fluids. Furthermore, the drugs ibuprofen and theophylline are crystalline with ibuprofen melting within the hot-melt extrusion process, whereas theophylline stays solid. These differences were taken into account for the calculation of the solubility... [Pg.247]


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See also in sourсe #XX -- [ Pg.376 ]




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