Rizatriptan drug interactions

The P-blockers propranolol and timolol are FDA-approved for migraine prophylaxis, but other drugs in the class are also as effective.46 Cautious dosage titration is advised for those patients who do not have other indications for P-blocker use. Rizatriptan interacts with propranolol and thus dosages must be titrated downward, or another triptan chosen for abortive therapy.36 Comorbid reactive airway disease is a relative contraindication to P-blocker prophylaxis, and patients with cardiac conduction disturbances should be closely monitored. Calcium channel antagonists are often used when patients cannot tolerate P-blockers. They are purported to beneficially... 

Sumatriptan Succinate Sumatriptan is a drug of abuse, and it interacts with ergotamine, serotonin, rizatriptan, antidepressants, and antipsychotics. 

Drugs used in the treatment of acute migraine, such as sumatriptan and rizatriptan, are 5-HTiB/iD-receptor agonists and could theoretically interact pharmacodynami-cally with SSRIs to cause serotonin toxicity. Triptans are metabolized mainly by monoamine oxidase, which makes pharmacokinetic interactions with SSRIs unlikely. Although case series have suggested that sumatriptan can be safely combined with SSRIs (SEDA-22, 14), there are occasional reports of toxicity. 

Clinically important, potentially hazardous interactions with citalopram, dihydroergotamine, ergot-containing drugs, escitalopram, fluoxetine, fluvoxamine, isocarboxazid, MAO inhibitors, methysergide, naratriptan, nefazodone, paroxetine, phenelzine, rizatriptan, sertraline, sibutramine, St John s wort, tranylcypromine, venlafaxine, zolmitriptan... 

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