Fatigue rituximab

Rituximab [Rituxan] Non-Hodgkin lymphoma Blood disorders [anemia, leukopenia, neutropenia, thrombocytopenia] hypertension hyperglycemia joint and muscle pain fatigue rash Gl distress [nausea, vomiting, diarrhea] others... 

Rituximab is used against malignant B lymphocytes that express the CD20 antigen. The mean serum half-life is S9.8 hours, with variability possibly reflecting the tumor burden. Adverse reactions include hypersensitivity or anaphylactic reactions, cardiac arrhythmias, nausea, fatigue, and urticaria. Fever and chills may occur during infusion. 

Most of the adverse effects of rituximab are infusion related, particularly after the first infusion, and consist of fever, chills, respiratory symptoms, fatigue, headache, pruritus, and angioedema. Premedication with oral acetaminophen 650 mg and diphenhydramine 50 mg is usually given 30 minutes before rituximab infusion. 

A teenage boy with focal segmental glomerulosclerosis developed rituximab-associated lung injury associated with progressive dyspnea, fever, hypoxemia, and fatigue 18 days after the completion of a second course of rituximab infusion for calcineurin inhibitor-dependent nephrotic syndrome [150 ]. 

Dass S, Bowman SJ, Vital EM, Ikeda K, Pease CT, Hamburger J, Richards A, Rauz S, Emery P. Reduction of fatigue in Sjogren syndrome with rituximab results of a randomised, double-blind, placebo-controlled pilot study. Ann Rheum Dis 2008 67(11) 1541. ... 

Monoclonal antibody therapy rituximab, alemtuzumab Non-specific immunotherapies and adjuvants BCG, interleukin-2 (IL-2), and interferon-a Immunomodulating drugs thalidomide and lenalidomide Cancer vaccines vaccine for advanced prostate cancer Side effects Flu-like symptoms, including fever, chills, nausea, and loss of appetite, allergic reactions, fatigue decrease in blood pressure Work better for some types of cancer than for others... 

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