Risk reduction carcinogens

Tubal ligation is another procedure that has shown potential for risk reduction. However, it is not recommended as a sole procedure in prophylaxis. Protective effect may be due to limiting exposure of the ovary to environmental carcinogens. A case-control study conducted by Narod and colleagues found that a history of tubal ligation in /f RCA-positive women was associated with a statistically significant 63% reduction in risk.22... 

Decision-makers have sometimes found presentations of comparative risk information a useful aid to the public discourse on risk acceptance. We referred in the last section, for example, to OSHA s use of statistics on the risks of job-related accidents to support decisions on risk reduction goals for workplace carcinogens. The agency noted that lifetime risks of death from injuries suffered in what most people perceive to be safe occupations do not go below about 1 per 1000. Data of these types were helpful in explaining why the agency settled on carcinogen risk levels in this range as sufficiently low to provide a safe work environment. 

The provisions may be related to concentration limits for the substance in a preparation or a product (e.g. emission limit for nickel in jewellery). There are also requirements for specific labelling and other safety measures (e.g. asbestos). A special mechanism for risk reduction in the Directive, that links the directive with Council Directive 67/548/EEC is provid by the 14th amendment in 1994. This Mlows substances classified as carcinogenic, mutagenic or toxic to reproduction (category 1 and 2) to be banned for consumer use. 

Determination of environmental carcinogens is not an end in itself. Although often misunderstood or misinterpreted, the aim of scientific work in this area is to collect data on human exposure, to pinpoint emission and immission sources and to determine the causes of potential health risks to humans. The ultimate aim is always elimination or reduction of human exposure and thereby prevention of human cancer. In view of the slow progress in the treatment of human cancer this approach is an important strategy in the fight against this disease. 

Another method that may have less carcinogenic potential is to topically deliver the photosensitizer (methoxsalen) to the skin by adding it to bath water (bath PUVA) or as a topical cream (PUVA cream) instead of through systemic administration. Advantages of this approach include minimal risk of systemic effects, overall reduction of PUVA dose to one-... 

Wang H, Tan W, Hao B, Miao X, Zhou G, He F, Lin D (2003a) Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK. Cancer Res 63 8057-8061... 

REACH introduces the concept of adequate control in EU chemical law. Traditionally, the term adequate control has been used to refer to good practice in the workplace. REACH now redefines adequate control in the form of risk management measures detailed in an exposure scenario necessary for the control of hazardous properties. Through a set of systematic procedures, risk management measures must be selected to reduce exposure below which adverse effects to human health or the environment are likely to occur (i.e., a DNEL, DMEL or PNEC). There is debate as to whether a concept of a safe level of exposure reduction, similar to adequate control, can apply to non-threshold carcinogens and mutagens, endocrine disruptors, persistent, bioaccumulative and toxic (PBT) or VPVB substances (e.g., [270]). Industry may need to demonstrate that exposure to these substances is always avoided or minimised, as specified in Annex I of the REACH Regulation. 

---