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Ring structures 6- membered rings

Macrolide antibiotics contain a many-membered lactone ring (14-membered rings for erythromycin and clarithromycin, and a 15-membered ring for azithromycin) to which are attached one or more deoxy sugars. Clarithromycin differs from erythromycin only by methylation of the hydroxyl group at the 6 position, and azithromycin differs by the addition of a methyl-substituted nitrogen atom into the lactone ring. These structural modifications improve acid stability and tissue penetration and broaden the spectrum of activity. [Pg.160]

Problem 18.56. All of the six-membered cyclic structures are incorrect from the viewpoint of conveying the correct bond angles for the atoms of the ring. Six-membered rings are not flat (Sec. 11.8). They are nonplanar, puckered chair structures which allow the bond angles to be the stable tetrahedral bond angle (109.5°). Draw the o- and /3-anomers of o-glucose in the chair structure. [Pg.370]

Analysis This cage-like structure contains 6, 5 and 4-membered rings we are most interested in the 4, and can disconnect this in two ways ... [Pg.97]

In spite of the diverse nature of alkaloid structures, two structural units, i.e. fused pyrrolidine and piperidine rings in different oxidation states, appear as rather common denominators. We therefore chose to give several examples for four types of synthetic reactions which have frequently been used in alkaloid total synthesis and which provide generally useful routes to polycyclic compounds with five- or six-membered rings containing one nitrogen atom. These are ... [Pg.289]

In the alkylative cyclization of the 1,6-enyne 372 with vinyl bromide, formation of both the five-membered ring 373 by exn mode carbopalladation and isomerization of the double bonds and the six-membered ring 374 by endo mode carbopalladation are observed[269]. Their ratio depends on the catalytic species. Also, the cyclization of the 1,6-enyne 375 with /i-bromostyrene (376) affords the endo product 377. The exo mode cyclization is commonly observed in many cases, and there are two possible mechanistic explanations for that observed in these examples. One is direct endo mode carbopalladation. The other is the exo mode carbopalladation to give 378 followed by cyclopropana-tion to form 379, and the subsequent cyclopropylcarbinyl-homoallyl rearrangement affords the six-membered ring 380. Careful determination of the E or Z structure of the double bond in the cyclized product 380 is crucial for the mechanistic discussion. [Pg.180]

It IS no accident that sections of our chair cyclohexane drawings resemble saw horse projections of staggered conformations of alkanes The same spatial relationships seen m alkanes carry over to substituents on a six membered ring In the structure... [Pg.119]

A compound (CgHjo) contains a five membered ring When Bt2 adds to it two diaste reomenc dibromides are formed Suggest reasonable structures for the compound and the two dibromides... [Pg.325]

Beginning in the 1980s research directed toward the isolation of new drugs derived from natural sources identified a family of tumor inhibitory antibiotic substances characterized by novel struc tures containing a C C—C=C—C C unit as part of a nine or ten membered ring With one double bond and two triple bonds (-ene + di- + -yne) these com pounds soon became known as enediyne antibiotics The simplest member of the class is dynemian A most of the other enediynes have even more compli cated structures... [Pg.368]

Firefly lucifenn is an example of an azole that contains a benzene ring fused to the five membered ring Such structures are fairly common Another example is benzimidazole present as a structural unit m vitamin B12 Some compounds related to benzimidazole include purine and its ammo substituted derivative adenine one of the so called het erocychc bases found m DNA and RNA (Chapter 28)... [Pg.461]

The enzyme catalyzed reactions that lead to geraniol and farnesol (as their pyrophosphate esters) are mechanistically related to the acid catalyzed dimerization of alkenes discussed m Section 6 21 The reaction of an allylic pyrophosphate or a carbo cation with a source of rr electrons is a recurring theme m terpene biosynthesis and is invoked to explain the origin of more complicated structural types Consider for exam pie the formation of cyclic monoterpenes Neryl pyrophosphate formed by an enzyme catalyzed isomerization of the E double bond m geranyl pyrophosphate has the proper geometry to form a six membered ring via intramolecular attack of the double bond on the allylic pyrophosphate unit... [Pg.1089]

Write a resonance form for guanine in which the six membered ring has an electronic structure analogous to benzene Show all unshared pairs... [Pg.1158]

The distorted structure can be replaced by a more reasonable structure using an empir ical molecular mechanics calculation This calculation which is invoked m Spartan Build by clicking on Minimize, automatically finds the structure with the smallest strain energy (m this case a structure with realistic bond distances and a boat conformation for the SIX membered ring)... [Pg.1263]

This polymerization is carried out in the two stages indicated above precisely because of the insolubility and infusibility of the final product. The first-stage polyamide, structure [IX], is prepared in polar solvents and at relatively low temperatures, say, 70°C or less. The intermediate is then introduced to the intended application-for example, a coating or lamination-then the second-stage cyclization is carried out at temperatures in the range 150-300°C. Note the formation of five-membered rings in the formation of the polyimide, structure [X], and also that the proportion of acid to amine groups is 2 1 for reaction (5.II). [Pg.335]

Fig. 3. Model of the crystal structure of the mineral mordenite showing the main channel formed by 12-membered ring and small channels which contain some of the sodium cations. Synthetic types of mordenite exhibit the adsorption behavior of a 12-membered ring, whereas the mineral does not, probably... Fig. 3. Model of the crystal structure of the mineral mordenite showing the main channel formed by 12-membered ring and small channels which contain some of the sodium cations. Synthetic types of mordenite exhibit the adsorption behavior of a 12-membered ring, whereas the mineral does not, probably...
When two heteroatoms are present in a saturated six-membered ring their effects are approximately additive. Apart from the case of two a oxygen atoms—in 1,3-dioxane (48) the shift of C-2 is S 95.4 instead of 5 108 which a double shift of 40 p.p.m. would require—predictions of shift made on this basis are usually accurate to within 5 p.p.m. and are generally much closer than this. Observed shifts for a few representative examples are shown in structures (48)-(52). [Pg.15]


See other pages where Ring structures 6- membered rings is mentioned: [Pg.305]    [Pg.471]    [Pg.452]    [Pg.5344]    [Pg.227]    [Pg.181]    [Pg.57]    [Pg.54]    [Pg.109]    [Pg.326]    [Pg.515]    [Pg.335]    [Pg.459]    [Pg.94]    [Pg.130]    [Pg.436]    [Pg.450]    [Pg.61]    [Pg.451]    [Pg.1]    [Pg.2]    [Pg.2]    [Pg.3]    [Pg.4]    [Pg.5]    [Pg.6]    [Pg.7]    [Pg.8]    [Pg.9]    [Pg.10]    [Pg.11]    [Pg.12]    [Pg.13]    [Pg.14]    [Pg.15]    [Pg.16]   
See also in sourсe #XX -- [ Pg.261 , Pg.262 ]




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14-membered ring structures

14-membered ring structures

18-membered ring structures, large pore zeolite

18-membered ring structures, large pore zeolite molecular sieves

18-membered ring structures, large pore zeolite silicates

24-membered phosphate ring structures

5-Membered rings structural types

Alkenes derivatives, five-membered ring structure

Allylic oxidation 14-membered ring structures

Five-membered ring structures, -coordination

Heteroaromatic compounds five-membered aromatic ring structures

Molecular sieves 12-membered ring structures

Olefins derivatives, five-membered ring structure

Ring compounds, structure eight-membered

Ring compounds, structure five-membered

Ring compounds, structure four-membered

Ring compounds, structure seven-membered

Ring compounds, structure three-membered

Ring structure five-membered rings

Ring structure seven-membered rings

Ring structure three-membered thiirane rings

Ring structures

STRUCTURE OF THREE-MEMBERED RINGS WITH TWO HETEROATOMS

Silicates 12-membered ring structures

Six-membered ring structures

Structure comprising Two Five-Membered Rings

Structure of Five-membered Rings with One Heteroatom

Structure of Five-membered Rings with Two or More Heteroatoms

Structure of Six-membered Rings

Thiophene derivatives five-membered ring structure

Titanium compounds 14-membered ring structures

Zinc compounds 24-membered ring structures

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