Ribozyme technology

Figure 14.16 Outline of how ribozyme technology could prevent translation of specific mRNA, thus preventing synthesis of a specific target protein...

Freelove, A.L. Zhang, R. The power of ribozyme technologies the logical way ahead for molecular medicine and gene therapy Curr. Opin. Mol. Ther. 2002, 4 (5), 419-422. 

Profile Founded in 1992, the company commercializes patented ribozyme technology in the human therapeutic, agricultural, animal health, and diagnostic fields, through both internal efforts and collaborations with strategic partners. It announced a collaboration with Protogene Laboratories, Inc. in December 1996 one goal is to create an instrument that will synthesize thousands of RPI s proprietary nuclease resistant ribozymes, combinatorial libraries of other compounds, and methods that allow for low-level quantitative detection of RNA in cells. 

The application of ribozyme technology as a form of therapy in humans may be possible, and in vitro stud-... 

Another state-of-the-art technique introduced in in vitro (and in vivo as well) transcriptions is the use of an RNA transcript-trimming plasmid which incorporates a ribozyme technology (70,71). A typical vector construct has the configura-... 

RIBOZYME TECHNOLOGY 1 HAMMERHEAD RIBOZYMES AS TOOLS FOR THE SUPPRESSION OF GENE EXPRESSION... 

RIBOZYME TECHNOLOGY 2 NOVEL ALLOSTERICALLY CONTROLLABLE RIBOZYMES, THE MAXIZYMES, WITH CONSIDERABLE POTENTIAL AS GENEINACTIVATING AGENTS... 

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