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Rheumatoid arthritis signaling cascades

The protein p56 lymphoid T-cell tyrosine kinase (Lck) is predominantly expressed in T lymphocytes where it plays a critical role in T-cell-mediated immune response. Lck participates in phosphotyrosine-dependent protein-protein interactions through its modular binding unit, the Src homology-2 (SH2) domain. SH2 domains are noncatalytic modules of about 100 amino acid residues that play important roles in intracellular signal transduction and represent potential targets for pharmacological intervention. Failure of the p5 6 Lck S H 2 domain to bind to immunoreceptor tyrosine-based activation motifs (ITAMs) of CD3 hampers the T-cell receptor (TCR) proximal activation process and suppresses the downstream T-cell activation signaling cascades [143]. Small compounds that would be able to block Lck SH2 domain-dependent protein-protein interactions could find therapeutic utility as immunosuppressants and in the treatment of T-cell leukemias, lymphomas, and autoimmune diseases such as rheumatoid arthritis. [Pg.452]


See other pages where Rheumatoid arthritis signaling cascades is mentioned: [Pg.208]    [Pg.19]    [Pg.406]    [Pg.179]    [Pg.214]    [Pg.19]    [Pg.208]    [Pg.1788]    [Pg.98]    [Pg.148]    [Pg.98]   
See also in sourсe #XX -- [ Pg.179 ]




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