Rheumatic disease glucocorticoids

Mathies H. Probleme der symptomatischen Therapie rheu-matischer Erkrankungen mit Glukokortikoiden und nicht-steroidalen Antirheumatika. [Problems in symptomatic therapy of rheumatic diseases with glucocorticoids and nonsteroidal antirheumatic agents.] Internist (Berl) 1979 20(9) 414-25. 

Glucocorticoids are used widely in the treatment of a variety of rheumatic disorders and are a mainstay in the treatment of the more serious inflammatory rheumatic diseases, such as systemic lupus erythematosus, and a variety of vasculitic disorders, such as polyarteritis nodosa, Wegener s granulomatosis, Churg-Strauss syndrome, and giant cell arteritis. 

Sensory systems Vision Steroid cataract is one of the most serious adverse reactions to glucocorticoids, because it affects quality of life. The risk factors for steroid cataracts in children with rheumatic diseases were initiation of glucocorticoid therapy in children under 12 years of age and intravenous methylprednisone pulse therapy [5 ]. 

Aikawa NE, Campos LMA, Silva CA, Carvalho JF, Saad CGS, Trudes G, et al. Glucocorticoid major factor for reduced immunogenicity of 2009 influenza A (HlNl) vaccine in patients with juvenile autoimmune rheumatic disease. J Rheumatol 2012 39(l) 167-73. 

The adrenal cortex synthesizes corticosteroids (glucocorticoids and mineralocor-ticoids), which differ in activities. In humans, cortisol is the main glucocorticoid, and aldosterone is a main mineralocorticoid. Steroid therapy causes severe potential side effects, hence a careful consideration is always exercised before starting therapy. These are used in variety of disorders such as rheumatic disorder, renal disease, allergic manifestation, bronchial asthma, skin diseases, infectious diseases, malignancy, and hepatic diseases. 

The glucocorticoids are used as replacement tlierapy for adrenocortical insufficiency, to treat allergic reactions, collagen diseases (eg, systemic lupus erytliemato-sus), dermatologic conditions, rheumatic disorders, shock, and otlier conditions (see Display 50-1). The anti-inflammatory activity of tliese honnones make them valuable as anti-inflammatories and as immunosuppressants to suppress inflammation and modify tlie immune resporisa... 

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