Cyclic RGD

H. N-methylated cyclic RGD peptides as highly active and selective (X,P3 integrin antagonists. J. Med. Chem. 1999, 42, 3033-3040. 

Annis, D. A. Helluin, 0. Jacobsen, E. N. (1998) Stereochemistry as a diversity element solid-phase synthesis of cyclic RGD peptide derivatives via asymmetric Catalysis., Chem., Int. Ed. Engl, 37, 1907-1909. 

Cyclic RGD peptides GPIIb/IIIa/platelets Thrombosis 94-106... 

Wessjohann and coworkers described the design and synthesis of cyclic RGD pentapeptoids and related derivates by consecutive Ugi reactions (Scheme 23) [93]. 

M. Ogawa, K. Hatano, S. Oishi, Y. Kawasumi, N. Fujii, M. Kawaguchi, R. Doi, M. Imamura, M. Yamamoto, K. Ajito, T. Mukai, H. Saji, K. Ito, Direct electrophilic radiofluorination of a cyclic RGD peptide for in vivo alpha(v)beta(3) integrin related tumor imaging, Nucl. Med. Biol. 30 (2003) 1-9. 

Other i j[CH2—S] peptides that have been reported include both agonists and antagonists of LHRH,t35 51] a series of linear enkephalins,]39 a cyclic mini-somatostatin,]52] and cyclic RGD cell-adhesion antagonists.]53 ... 

Zhu J, Tang C, Kottke-Marchant K et al (2009) Design and synthesis of biomimetic hydrogel scaffolds with controlled organization of cyclic RGD peptides. Bioconjug Chem 20(2) 333-339... 

Kantlehner M, Schaffner P, Finsinger D et al (2000) Surface coating with cyclic RGD peptides stimulates osteoblast adhesion and proliferation as well as bone formation. Chembiochem... 

Buerkle MA, Pahernik SA, Sutter A, Jonczyk A, Messmer K, Dellian M. Inhibition of the alpha-nu integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo. Br J Cancer 2002 86 788-795. 

Wessjohann and coworkers reported in 2008, a concise synthesis of cyclic RGD pentapeptoids by three consecutive Ugi-4CR including one for macrocyclization [63]. Thus, reaction of 23, obtained from 22 in two steps, with formaldehyde and ferf-butyl isocyanide in methanol afforded, after global deprotection under acidic conditions, the pentapeptoid 24 in 33% yield in four steps (Scheme 9). 

Dubey, et al. (2004). Liposomes modified with cyclic RGD peptide for tumor targeting. J Drug Target. 12, 257-264. 

Su ZF, Liu G, Gupta S et al (2002) In vitro and in vivo evaluation of a technetium-99m-labelled cyclic RGD petide as a specific marker of integrin for tumor imaging. Bioconjug Chem 13 561-570... 

Researchers at SmithKline Beecham Pharmaceuticalsinvestigated the structure of the cyclic RGD-containing compound 59 (SK F 107260), a... 

Akaji, K. Teruya. K. Akaji, M. Aimoto. S. Synthesis of cyclic RGD derivatives via solid phase macrocyclization using the Heck reaction. Tetrahedron 2001. 57. 2293-2303. 

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