Reviews of antibacterial activity

Verhaegen, ibid. 807. In vitro comparison with other (J-hctams R. Wise et al, ibid. 884 L. Verbist, ibid. 19, 407 (1981). Symposium on clinical studies J. Antimicrob. Che-mcxfier. 12, Snppl. A, 1-414 (1983). Review of antibacterial activity, pharmacokinetics and therapeutic use D M. 

J.F. Siqueira, H.P. Lopes, Mechanisms of antibacterial activity of calcium hydroxide a critical review, Int. Endod. J. 32 (1999) 362-369. 

Mechanism of Antibacterial Action. In spite of the fact that the antibacterial activity of the amiaoglycosides has been known siace the 1940s, the mechanisms iavolved are stiU incompletely understood. Numerous reviews have appeared (eg, 108 —113) and the sequence of events seems to be as outlined below. 

Clavulanic acid has only weak antibacterial activity, but is a potent irreversible inhibitor for many clinically important P-lactamases (10—14,57,58) including penases, and Richmond-Sykes types 11, 111, IV, V, VI ([Bacteroides). Type I Cephases are poorly inhibited. Clavulanic acid synergizes the activity of many penicillins and cephalosporins against resistant strains. The chemistry (59—63), microbiology (64,65), stmcture activity relationships (10,13,60—62,66), biosynthesis (67—69), and mechanism of action (6,26,27,67) have been reviewed. 

Dactinomycin, an antineoplastic dmg, was discovered in 1943 and is made in rather pure form by StreptomjcesparvuUus. Dactinomycin has some bacteriostatic antibacterial and antifungal activity, but high toxicity limits its use to antineoplastic therapy. It may be used alone or with other antineoplastics, with or without surgery and synergistic x-ray therapy. Dose limiting bone marrow toxicity may result in low white cell and platelet count. Intestinal mucosal damage also occurs. Reviews of more detailed chemotherapeutic information are available (217—222). 

As can be seen from Table 3, only modifications at the 6/3-amino groups have been successful in producing penicillins of medical significance up to this time. Several reviews have dealt with the structure-activity relationship in this area in considerable detail B-80MI51102, B-77MI51106, B-75MI51102) and should be consulted for the actual effects of structural modification on antibacterial activity. 

Gillis JC, Brogden RN Rifaximin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential in conditions mediated by gastrointestinal bacteria. Drugs 1995 49 467-484. 

The purpose of this review is to discuss recent developments related to the chemistry and medicinal properties of natural flavonoids. This review covers more recent reports (2005 to the present date) of antimicrobial activity of flavonoids (antibacterial and antifungal), as well as the antiviral activity of these compounds. 

The coordination shell comprises three fac-S and three fac-N-donor atoms in [Fe(6mp)3] [FeClJCl, where 6mp = 6-thiopurine, (189). Both iron(II) and iron(III) complexes are included in a review of transition metal complexes of thiosemicarbazones. " 5,5 -Dimethyl-l,2,3-cyclohex-anetrione-l,2-dioxime-3-thiosemi-carbazone, dcdt (190), acts as an A, A, 5 -donor to Fe +, giving a bis-ligand complex (contrast [Fe(7V,7V -dcdt)3] with Fe " "). The Schiff bases from pyridine 2-carboxaldehyde and thiosemicarbazide or 4-phenyl thiosemicarbazide also act as A, VV, 5 -donors, both to Fe " " and to Fe " ". The antibacterial activity of these complexes was assessed, in... 

The secondary metabolites of the endophytic fungi associated with dicotyledonous plants (dicots) are chemically diverse (Table 1). There is an equal diversity in the activities of these compounds, including antibacterial, antifungal, nematicidal, phytotoxic, cytotoxic, antineoplastic, anti-insectant, anti-herbivory, and a variety of other activities. The compounds isolated, structurally elucidated, and explored biologically in the short time since previous reviews continue to display that same wide array of chemical and biological diversity. 

---