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Barrier retinal

The retina comprises two principal components, the non-neural retinal pigment epithelium and the neural retina. The retinal pigment epithelium is an essential component of the visual system both structurally and functionally. It is important for the turnover and phagocytosis of photoreceptor outer segments, the metabolism of retinoids, the exchange of nutrients between the photoreceptors, and the choroidal blood vessels and the maintenance of an efficient outer blood-retinal barrier. [Pg.134]

The significance of the barrier function of membranes has been the topic of considerable research. The blood-brain barrier and the blood-retinal barrier are well understood, and the microscopic structures imparting and controlling barrier properties have been quite thoroughly investigated and the science reviewed [15, 154-155], The structures and functions of ocular membranes specific to transport associated with ophthalmic drug administration also have been topics of extensive research [15, 157-158],... [Pg.435]

Inner Blood-Retinal Barrier Transport Biology and Methodology... [Pg.321]

Keywords Inner blood-retinal barrier Transporter Influx transport Efflux transport Microdialysis Cell line Drug delivery... [Pg.321]

Blood-retinal barrier inner Blood-retinal barrier... [Pg.323]

Figure 14.1 Schematic diagram of the blood-retinal barrier (BRB). The retinal cell layers seen histologically consist of retinal pigment epithelium (RPE) photoreceptor outer segments (POS) outer limiting membrane (OLM) outer nuclear layer (ONL) outer plexiform layer (OPL) inner nuclear layer (INL) inner plexiform layer (IPL) ganglion cell layer (GCL) nerve fiber layer (NFL) inner limiting membrane (ILM). Figure 14.1 Schematic diagram of the blood-retinal barrier (BRB). The retinal cell layers seen histologically consist of retinal pigment epithelium (RPE) photoreceptor outer segments (POS) outer limiting membrane (OLM) outer nuclear layer (ONL) outer plexiform layer (OPL) inner nuclear layer (INL) inner plexiform layer (IPL) ganglion cell layer (GCL) nerve fiber layer (NFL) inner limiting membrane (ILM).
Conditionally Immortalized Cell Lines as a Novel in Vitro Inner Blood-Retinal Barrier Model (Uptake Studies)... [Pg.324]

Figure 14.2 Phase contrast microscopic images of conditionally immortalized cells forming the inner blood-retinal barrier (A) and time-course of [3H] adenosine uptake by TR-iBRB cells (B). A Conditionally immortalized rat retinal capillary endothelial cell line TR-iBRB, retinal pericyte cell line TR-rPCT and Muller cell line TR-MUL. B The [ H]adenosine (14 nM) uptake was performed at 37°C in the presence (closed circle) or absence (open circle) of Na+. Figure 14.2 Phase contrast microscopic images of conditionally immortalized cells forming the inner blood-retinal barrier (A) and time-course of [3H] adenosine uptake by TR-iBRB cells (B). A Conditionally immortalized rat retinal capillary endothelial cell line TR-iBRB, retinal pericyte cell line TR-rPCT and Muller cell line TR-MUL. B The [ H]adenosine (14 nM) uptake was performed at 37°C in the presence (closed circle) or absence (open circle) of Na+.
Figure 14.3 Integration plot of the initial uptake of [3H]adenosine by the retina after intravenous administration (A) and retinal uptake index (RUI) of [3H]adenosine and [3H]D-mannitol (B). A [3H]Adenosine (10 //.Ci/head) was injected into the femoral vein. B A test compound, [3H]adenosine or [3H]D-mannitol (10 //Ci/head), and a reference compound, [14C]n-butanol (0.1 //Ci/head), were injected into the common carotid artery in the presence or absence of 2 mM inhibitors. p < 0.05, significantly different from the control. Data from Biochimica et Biophysica Acta, 1758, Nagase et al., Functional and molecular characterization of adenosine transport at the rat inner blood-retinal barrier. 13-19, 2006, with permission from Elsevier. Figure 14.3 Integration plot of the initial uptake of [3H]adenosine by the retina after intravenous administration (A) and retinal uptake index (RUI) of [3H]adenosine and [3H]D-mannitol (B). A [3H]Adenosine (10 //.Ci/head) was injected into the femoral vein. B A test compound, [3H]adenosine or [3H]D-mannitol (10 //Ci/head), and a reference compound, [14C]n-butanol (0.1 //Ci/head), were injected into the common carotid artery in the presence or absence of 2 mM inhibitors. p < 0.05, significantly different from the control. Data from Biochimica et Biophysica Acta, 1758, Nagase et al., Functional and molecular characterization of adenosine transport at the rat inner blood-retinal barrier. 13-19, 2006, with permission from Elsevier.
Ex Vivo Transporter Gene Expression Levels at the Inner Blood-Retinal Barrier (Magnetic Isolation of Retinal Vascular Endothelial Cells)... [Pg.330]

Figure 14.5 Schematic diagram of the magnetic isolation method for rat retinal vascular endothelial cells (RVEC) (A) and the transcript level of organic anion-transporting polypeptides (Oatps) in RVEC (B). A Endothelial cells (RVEC) EC, Nonendothe-lial cells (Non-RVEC) Non-EC. B Not detected N.D. Data taken from Journal of Neurochemistry, 91, Tomi and Hosoya, Application of magnetically isolated rat retinal vascular endothelial cells for the determination of transporter gene expression levels at the inner blood-retinal barrier. 1244-1248, 2004, with permission from Blackwell Publishing. Figure 14.5 Schematic diagram of the magnetic isolation method for rat retinal vascular endothelial cells (RVEC) (A) and the transcript level of organic anion-transporting polypeptides (Oatps) in RVEC (B). A Endothelial cells (RVEC) EC, Nonendothe-lial cells (Non-RVEC) Non-EC. B Not detected N.D. Data taken from Journal of Neurochemistry, 91, Tomi and Hosoya, Application of magnetically isolated rat retinal vascular endothelial cells for the determination of transporter gene expression levels at the inner blood-retinal barrier. 1244-1248, 2004, with permission from Blackwell Publishing.
Mechanism of Drug Transport at the Inner Blood-Retinal Barrier... [Pg.332]

K. Hosoya and M. Tomi. Advances in the cell biology of transport via the inner blood-retinal barrier Establishment of cell lines and transport functions. Biol. Pharm. Bull. 28 1-8 (2005). [Pg.335]

J. G. Cunha-Vaz. The blood-retinal barriers system. Basic concepts and clinical evaluation. Exp. Eye Res. 78 715-721 (2004). [Pg.335]

A. Aim and P. Tornquist. The uptake index method applied to studies on the blood-retinal barrier. I. A methodological study. Acta Physiol. Scand. 113 73-79 (1981). [Pg.335]

K. Katayama, Y. Ohshima, M. Tomi, and K. Hosoya. Application of microdialysis to evaluate the efflux transport of estradiol 17-/7 glucuronide across the rat blood-retinal barrier. J. Neurosci. Methods 156 249-256 (2006). [Pg.335]

M. Tomi and K. Hosoya. Application of magnetically isolated rat retinal vascular endothelial cells for the determination of transporter gene expression levels at the inner blood-retinal barrier. J. Neurochem. 91 1244—1248 (2004). [Pg.336]

T. Nakashima, M. Tomi, K. Katayama, M. Tachikawa, M. Watanabe, T. Terasaki, and K. Hosoya. Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-retinal barrier. J. Neumchem. 89 1454—1461... [Pg.336]

S. L. Lightman, A. G. Palestine, S. I. Rapoport, and E. Rechthand. Quantitative assessment of the permeability of the rat blood-retinal barrier to small water-soluble non-electrolytes. J. Physiol. 389 483 190 (1987). [Pg.336]

K. Takata, T. Kasahara, M. Kasahara, O. Ezaki, and H. Hirano. Ultracytochemical localization of the erythrocyte/HepG2-type glucose transporter (GLUT1) in cells of the blood-retinal barrier in the rat. Invest. Ophthalmol. Vis. Sci. 33 377-383 (1992). [Pg.337]

M. Tomi, K. Hosoya, H. Takanaga, S. Ohtsuki, and T. Terasaki. Induction of the xCT gene expression and L-cystine transport activity by diethyl maleate at the inner blood-retinal barrier. Invest. Ophthalmol. Vis. Sci. 43 774—779 (2002). [Pg.337]

M. Tomi, T. Terayama, T. Isobe, F. Egami, A. Morito, M. Kurachi, S. Ohtsuki, Y. S. Kang, T. Terasaki, and K. Hosoya. Function and regulation of taurine transport at the inner blood-retinal barrier. Microvasc. Res. 73 100-106 (2007). [Pg.338]

See other pages where Barrier retinal is mentioned: [Pg.804]    [Pg.423]    [Pg.321]    [Pg.321]    [Pg.322]    [Pg.323]    [Pg.323]    [Pg.330]   


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