Reticuloendothelial organs

Yamada H, Johnson DE, Griswold ML et al (1969) Radioalbumin microaggregates for reticuloendothelial organ scanning and function assessment. J Nucl Med 10 453-454... 

SWCNTs were mostly cleared from the systemic blood circulation system through renal excretion at 3 h and they were not found to be retained by the reticuloendothelial organs. Later, Liu et reported that the PEGylated SWCNTs showed a longer blood circulation time after intravenous injection in mice than the surfactant-suspended pristine SWCNTs in rabbits. Their... 

In normal human subjects, some 25 % of total body iron (800-1000 mg) is present in the storage forms, mostly as ferritin. Whereas it is likely that all mammalian cell types contain some ferritin, haemosiderin in normal subjects is essentially restricted to cells of the reticuloendothelial system. Ferritin turns out to be almost universal in its distribution ferritin and ferritin-like proteins have been found in all organisms except for one or two archaebacteria. In contrast, haemosiderin has not been found to any extent outside of iron-loaded animals, except for a brief report of a phytosiderin in pea seeds (Laulhere et ah, 1989). 

Heme is mainly found in the human organism as a prosthetic group in erythrocyte hemoglobin. Around 100-200 million aged erythrocytes per hour are broken down in the human organism. The degradation process starts in reticuloendothelial cells in the spleen, liver, and bone marrow. 

Lee, M.-J., Lee, M.-H., and Shim, C.-K. (1995) Inverse targeting of drugs to reticuloendothelial system-rich organs by lipid microemulsion emulsi.ed with poloxamer 3SB.J. Pharm., 113 175-187. 

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