Respiratory Function in Monkeys and Dogs

Species other than the rat may be required to address specific study requirements. For example, the development of humanized monoclonal antibodies or other 

To monitor arterial blood pressure, a 4 cm incision is made over the right femoral region and the femoral artery is isolated. A trocar is used to pass the blood pressure catheter from the abdomen to the femoral incision. An arterotomy is made in the femoral artery and the catheter introduced 10 cm into the artery and the catheter secured using standard techniques. 

Surgical Recovery and Training After surgery, the monkeys are allowed to recover for at least three weeks prior to the start of the study. All monkeys are observed daily for signs of pain or distress and body weights are obtained at least weekly. All monkeys should be acclimated to handling, chair restraint, and the helmet used for respiratory measurements on at least 3 occasions prior to the start of each study. In addition, prior to implantation of the telemetry device, each monkey should be acclimated to the restraint chair and helmet for approximately 60 minutes on at least six occasions to ensure that the animals have the appropriate temperament. 

Murphy DJ, Renninger JP, Gossett KA (1998) A novel method for chronic measurement of pleural pressure in conscious rats. Journal of Pharmacological and Toxicological Methods 39 137-141 

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