Resolution two-dimensional

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Young DA, Voris BP, Maytin EV, Colbert BA. (1983) Very-high-resolution two-dimensional electrophoretic separation of proteins on giant gels. MethodsEnzymol9, 190-214. 

WUdgruber R, Harder A, Obermaier C, et al. (2002) Towards higher resolution two-dimensional electrophoresis of Saccharomyces cerevisiae proteins using overlapping narrow immobUized pH gradients. Electrophoresis2, 2610-6. 

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Latner AL, Marshall T, Gambie M. A simplified technique of high-resolution two-dimensional electrophoresis serum immunoglobulins. Clin ChimActa 1980 103 51-59. 

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E-C Muller, M Schumann, A Rickers, K Bommert, B Wittmann-Liebold, A Otto. Study of Burkitt lymphoma cell line proteins by high resolution two-dimensional gel electrophoresis and nanoelectrospray mass spectrometry. Electrophoresis 20 320-330, 1999. 

Significant improvements in the technologies of high-resolution two-dimensional Polyacrylamide Gel Electrophoresis (2-D PAGE) and Mass Spectrometry (MS) have marked the start of proteome analysis. Proteomics permits the analysis of thousand of proteins simultaneously, and have the potential to identify markers for early detection, classification and prognosis of diseases, as well as pinpointing targets for improved treatment outcomes [42]. 

In this context, the aim of this study is to use a microscale (5 cm resolution) two-dimensional sampler to investigate (i) the heterogeneity of the microscale distributions of phytoplankton biomass and bulk-phase seawater viscosity, (ii) the potential changes in these distributions over the course of a P. globosa spring bloom and (iii) the nature of the correlation between seawater viscosity and phytoplankton before, during and after the formation of foam in the turbulent surf zone. 

Gorg, A., and Weiss, W. (1998). High-resolution two-dimensional electrophoresis of proteins using immobilized pH gradients. In Cell Biology A Laboratory Handbook (J. E. Celis, ed.), 2nd ed., Vol. 4, pp. 386-397. Academic Press, San Diego, CA. 

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