High-resolution two-dimensional

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E-C Muller, M Schumann, A Rickers, K Bommert, B Wittmann-Liebold, A Otto. Study of Burkitt lymphoma cell line proteins by high resolution two-dimensional gel electrophoresis and nanoelectrospray mass spectrometry. Electrophoresis 20 320-330, 1999. 

Significant improvements in the technologies of high-resolution two-dimensional Polyacrylamide Gel Electrophoresis (2-D PAGE) and Mass Spectrometry (MS) have marked the start of proteome analysis. Proteomics permits the analysis of thousand of proteins simultaneously, and have the potential to identify markers for early detection, classification and prognosis of diseases, as well as pinpointing targets for improved treatment outcomes [42]. 

Gorg, A., and Weiss, W. (1998). High-resolution two-dimensional electrophoresis of proteins using immobilized pH gradients. In Cell Biology A Laboratory Handbook (J. E. Celis, ed.), 2nd ed., Vol. 4, pp. 386-397. Academic Press, San Diego, CA. 

He, C., Muller, U., Werdan, K. (1992a). Regulation of protein biosynthesis in neonatal rat cardiomyocytes by adrenoceptor-stimulation investigations with high resolution two-dimensional polyacrylamide gel electrophoresis. Electrophoresis 13, 755-756. 

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