Secondary products resistance against

Another field of research is the possibility offered by phytochemicals in protecting plants against diseases and pathogens (fungus, bacteria and nematodes). Numerous studies have suggested that plant-pathogen interactions are partially mediated via plant secondary metabolite production, despite the inconsistency revealed by some works on the ability of particular compounds to provide resistance to a specific pathogen. 

Saquinavir is a peptide-like substrate analog that inhibits HIV protease after binding to its active site and is active against both HIV-1 and HIV-2 maturation. It blocks splicing of the viral polyproteins, which results in the production of immature viral particles that lack the ability to infect other cells. The resistance to saquinavir is associated with mutations in protease genes G48 V and L90 M, whereas secondary mutations are associated with codons 36, 46, 82, 84, 101, 154 and 184 multiple mutations are necessary to render strong resistance to the drug. 

The use of higher plants and their preparations to treat infections is an age-old practice and in times past possibly the only method available. Interest in plants with antimicrobial properties has revived because of the current problems associated with the use of penicillin and other antibiotics. Therapy with several types of antibiotics is frequently accompanied by side effects and microbial resistance. It is currently accepted that the accumulation of secondary metabolites in plants can be a consequence of requirements for chemical defense against microorganisms. Research carried out in the chemical and biological sciences has resulted in much evidence concerning the defensive role of natural products. 

In addition, commercial polyacetals are also stabilized with urea, hydrazine, or with polyamides against thermal degradation these additives react with formaldehyde or its reaction products, such as, for example, formic acid. Secondary and tertiary amines are also added to increase oxidation resistance. 

Evidence for or against roles of LOX and their products in higher plant growth, development, storage product and secondary metabolite accumulation and senescence is reviewed below. LOX/LOX products also have clear roles in plant resistance to pests as reviewed in Chapter 7. 

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