Reproductive system toxicity fertility

Reproductive Toxicity—The occurrence of adverse effects on the reproductive system that may result from exposure to a chemical. The toxicity may be directed to the reproductive organs and/or the related endocrine system. The manifestation of such toxicity may be noted as alterations in sexual behavior, fertility, pregnancy outcomes, or modifications in other functions that are dependent on the integrity of this system. 

In a continuous breeding study in mice reproductive and fertility parameters were not affected by gavage administration of ONCB even in the presence of systemic toxicity (significant methemoglobinemia and increased spleen and liver weights). Decreased spermatogenesis has been reported after inhalation exposure in rats and mice. 

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