Reproducibility processes, Good

The template-directed synthesis of nano- and micromaterials has considerably evolved in recent years. Efforts were driven by the demand to produce in a controlled and reproducible way nano- and microstructures with applications in materials science, catalysis, and pharmacy. The idea to use templates is an old idea of mankind to produce reliably and reproducibly household goods and artworks needed in everyday life. The requirements for the template can easily be seen in the production of pottery. A template is filled or covered with a soft precursor material to bring the material into the desired form. Through a chemical reaction or a physical process the precursor material hardens and the template can be removed to obtain the desired product. The template has the advantage that its size and shape can be reproducibly controlled, in contrast to the desired material, where such control is more difficult. 

The sensitivity of the shape of the low field absorption under various experimental conditions Is thought to be an extremely sensitive diagnostic tool for the local structure o a superconducting phase present as a disordered powder or glassy material on a microscopic scale. Exact reproducibility of the shape and Intensity of this signal under nominally analogous experimental conditions for different preparations Is hard to achieve. However semlquantltatlve reproducibility Is good. This may be an experimental problem at present, but we feel that It Is more likely due to subtle differences In the solid state compound formation process in different sample preparations. Additional work and other locally microscopic techniques are needed to clarify these aspects. 

Good manufacturing practices (GMP) are essential in medical extrusion and involve both a high level of sanitation and process reproducibility. Process reproducibility can be quantified with statistical techniques that have been developed in the field of statistical process control (SPC). Therefore, SPC is a necessary requirement in medical extrusion [107]. GMP also requires full documentation and traceability. With respect to medical extruder machine design, the following aspects are of great importance ... 

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