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Reporter gene assay methods

Sumida K, Ooe N, Nagahori H et al. (2001) An in vito reporter gene assay method incorporating metabolic activation with human and rat S9 or liver microsomes. Biochem Biophys Res Commun 280 85-91. [Pg.511]

Reporter gene assays that measure ER binding-dependant transcriptional and translational activity. The yeast-based assays fall within this group. The vast majority of yeast-based assays are based on S. cerevisiae containing a stably transfected human estrogen, receptor (hER), although there are several variations in strain and detection method (NICEATM, 2002)... [Pg.373]

As mentioned above, all the methods currently employed for measuring CYP3A4 induction, including humanized mice, PXR reporter gene assays, and primary cultures of human hepatocytes, have limitations. Most importantly. [Pg.562]

Caserman, S., Menart, V, Gaines Das, R., Williams, S. and Meager, A. Thermal stability of the WHO international standard of interferon alpha 2b (IFN-a2b) Application of new reporter gene assay for IFN-a2b potency determinations. J. Immunol. Methods 319 6-12, 2007. [Pg.357]

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Reporter assays

Reporter gene assay

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