Replication of deoxyribonucleic acid

Sueoka N. (1960). Mitotic replication of deoxyribonucleic acid in Chlamydomonas reinhardtii. Proc. Natl. Acad. Sci. USA 46, 83-91. 

True to their word Watson and Crick followed up their April 25 paper with another on May 30 This second paper Genetical Implications of the Struc ture of Deoxyribonucleic Acid outlines a mechanism for DNA replication that is still accepted as essentially correct... 

The discovery of the base-paired, double-helical structure of deoxyribonucleic acid (DNA) provides the theoretic framework for determining how the information coded into DNA sequences is replicated and how these sequences direct the synthesis of ribonucleic acid (RNA) and proteins. Already clinical medicine has taken advantage of many of these discoveries, and the future promises much more. For example, the biochemistry of the nucleic acids is central to an understanding of virus-induced diseases, the immune re-sponse, the mechanism of action of drugs and antibiotics, and the spectrum of inherited diseases. 

Latt, S.A. (1973). Microfluorometric detection of deoxyribonucleic acid replication in human metaphase chromosomes. Proc. Nat. Acad. Sci. U.S.A. 770 3395-3399. 

Another dinuclear Mn enzyme with quite a different functionality is MnRNR. Cell replication and deoxyribonucleic acid (DNA) formation require the reduction of the 2 hydroxyl group of a ribonucleoside phosphate [13a]. 

The hereditary material of the cell consists of deoxyribonucleic acid (DNA). DNA is similar to RNA, but the five carbon sugar, deoxyribose replaces ribose, and in place of uracil, the base thymine is found. DNA occurs as a double-stranded molecule. The two strands are held together by hydrogen bonds. DNA polymerase is one of the enzymes responsible for the process of replication whereby the double strands are separated and used as a template for the synthesis of new strands. Replication precedes cell division so that each new cell receives its own complement of double-stranded DNA. 

The genetic information that provides both the similarities and the differences befween fhese fwo tigers is fransferred from one generation to fhe nexf by fhe replication of molecules of deoxyribonucleic acid, or DNA. 

Mitra, S., Reichard, P, Inman, R.B. et al. (1967) Enzymic synthesis of deoxyribonucleic acid. XXII. Replication of a circular single-stranded DNA template by DNA polymerase of Escherichia coli. Journal of Molecular Biology,... 

The human brain grows at an increasingly rapid rate up to the end of gestation. After birth the growth rate slows down but continues to be rapid up to about two years of age. The growth of the brain, like that of all other tissues, takes place firstly by hyperplasia and later by hypertrophy. Using the total amount of deoxyribonucleic acid (DNA) as a measure of the total number of cells in the brain, Dobbing and Sands have shown that DNA replication takes place rapidly up... 

The passing-on of genetic information requires, as we have seen, identical replication of DNA, which means de novo synthesis of deoxyribonucleic acid in strict conformity with an existing template. 

Latt, S. A. Microfluorometric analysis of deoxyribonucleic acid replication kinetics and sister chromatid exchanges in human chromosomes. J. Histochem. Cytochem. 1974,22,478-491. 

Adams, R. L. P., Abrams, R., and Lieberman, L, 1966, Deoxycytidylate synthesis and entry into the period of deoxyribonucleic acid replication in rabbit kidney cells, J. Biol. Chem. 241 903. 

DNA (deoxyribonucleic acid) (Section 28 7) A polynucleotide of 2 deoxynbose present in the nuclei of cells that serves to store and replicate genetic information Genes are DNA... 

Deoxyribonucleic acid (DNA, Fig. 3-13) is the genetic material of all organisms, including plants, animals, and microorganisms. (Some viruses lack DNA, but use RNA (ribonucleic acid) in its place.) DNA carries all the hereditary information of the organism and is therefore replicated and passed from parent to offspring. RNA is formed on DNA in the nucleus of the... 

All biological organisms have the ability to reproduce themselves. The instructions for self-replication are stored and transmitted by macromolecules called nucleic acids. There are two types of nucleic acids, one that stores genetic information and one that transmits the information. Genetic information is stored in molecules of deoxyribonucleic... 

Deoxyribonucleic acid (DNA) topoisomerases (topos) are ubiquitous enzymes that can manipulate DNA by changing the number of topological links between two strands of the same or different DNA molecules [1]. These enzymes are involved in many cellular processes, such as replication, recom-... 

The nucleus contains bundles of a fibrous material known as chromatin, which is made up of mixed proteins and deoxyribonucleic acid (DNA), the substance that carries the genetic information of the living organism of which the cell is a component. All cells replicate by division. When a cell replicates, DNA in the chromatin of the nucleus passes the genetic information from one generation to the next one. As the cell divides, the chromatin clusters into rodlike structures known as chromo-... 

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